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Vaginal Indomethacin for Preterm Labor — TOCOMED  

Obstetric Labor, Premature Clinical Trial

Official title:
Vaginal Indomethacin Versus Oral Nifedipine for Preterm Labor; a Randomized Controlled Trial

Clinical Trial Summary

Indometacin is a cyclooxygenase agent from the NSAID family that has been used to treat preterm contractions since the 70's by preventing the synthesis of prostaglandins. It has been shown to be significantly more effective than placebo and postpone labor for 7-10 days, prolong pregnancies above 37 weeks of gestation and reduce numbers of small for gestational age neonates.

Nifedipine is a calcium channel blocker agent that has been shown to reduce rates of labor within 48 hours from treatment.

Previous studies comparing rectal Indometacin to oral nifedipine were inconclusive.

Prostaglandins are synthesized in the uterus and the uterine cervix and therefore local administration of Indometacin may be more effective than other forms of administration, as been shown in a previous study.

In this study we aim to compare vaginal Indometacin administration to a commonly used tocolytic agent, nifedipine.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04404686
Study type Interventional
Source Hadassah Medical Organization
Contact Hila Hochler, MD
Phone 00 972 52 300 3722
Email hilahochler@gmail.com
Status Not yet recruiting
Phase Phase 2/Phase 3
Start date October 2020
Completion date April 2025
View Details
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