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BMI-Driven Tolerability and Efficacy of Entresto in Heart Failure Patients — BETTER-HF  

Obesity Clinical Trial

Official title:
BMI-Driven Tolerability and Efficacy of Entresto in Heart Failure Patients

Clinical Trial Summary

This study aims to determine if patients with higher BMI can tolerate higher doses of Entresto (sacubitril/valsartan) and experience better symptomatic and functional outcomes compared to patients with lower BMI.

Clinical Trial Description

This prospective cohort study will enroll heart failure patients with reduced ejection fraction (HFrEF) to evaluate the tolerability and efficacy of Entresto uptitration across different BMI categories (Normal weight, Overweight, Obese, and Very Obese). Primary outcomes include the maximum tolerable dose and incidence of adverse drug reactions. Secondary outcomes include changes in heart failure symptoms, functional capacity measured by the 6-minute walk test, hospitalization rates, and mortality. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06439069
Study type Observational
Source Lithuanian University of Health Sciences
Contact Ali Aldujeli, MD., MSc
Phone +37064874874
Email ali.aldujeli@kaunoklinikos.lt
Status Recruiting
Phase
Start date August 10, 2023
Completion date December 1, 2024
View Details
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