Obesity Clinical Trial
Official title:
Understanding the Role of the Human Metagenome in Obesity, Metabolic Diseases, Chronic Inflammation, Sarcopenia and Sarcopenic Obesity - a Pilot Study
This is a cohort study to understand the role of the human metagenome, and associated metabolites, in health and in various diseased states, in particular obesity as well as sarcopenia. Recruited participants will have their fecal, salivary, urine, serum, and in certain instances, mucosal samples taken, for metagenomic sequencing and metabolite testing. We hope to uncover various differences and signatures in the metagenome and metabolome in various diseased states, with potential future therapeutic applications in personalised medicine.
Status | Recruiting |
Enrollment | 600 |
Est. completion date | December 31, 2027 |
Est. primary completion date | December 31, 2026 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 21 Years to 99 Years |
Eligibility | Inclusion Criteria (obese cohort): - Obese (BMI>27.5kg/m2) Inclusion Criteria (sarcopenic cohort): - Sarcopenic patients, defined as 1) low handgrip strength (<26 for males; <18kg for females), AND/OR low gait speed (<0.8m/s) AND low muscle mass (<7.0kg/m2 for males; <5.7kg/m2 for females) Inclusion Criteria (control cohort): - Healthy subjects without sarcopenia, and not obese (BMI<27.5kg/m2) Exclusion Criteria: - No informed consent - Presence of intestinal stoma, hence inability to collect fecal samples |
Country | Name | City | State |
---|---|---|---|
Singapore | Sengkang General Hospital | Singapore |
Lead Sponsor | Collaborator |
---|---|
Sengkang General Hospital | Duke-NUS Graduate Medical School, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore General Hospital |
Singapore,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Metagenomic alterations | Metagenomic alterations in the DNA/ RNA sequences of the saliva, stool (+/- mucosal) metagenome over time | Period of 1 year | |
Primary | Metabolomic alterations | Changes in serum and urinary charged metabolites and small molecules over time | Period of 1 year |
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