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Adaptive Mechanisms In GRown up ObeSity Study (AMIGROS) — AMIGROS  

Obesity Clinical Trial

Official title:
Mechanistic Studies in Human Subcutaneous Adipose Tissue

Clinical Trial Summary

The investigator recently showed that the glycan-binding adipokine galectin-1 increased during overfeeding and that galectin-1 independently could predict type 2 diabetes. Further, the molecules that induce insulin release in the fasting state when blood glucose is normal remain elusive. It is possible that galectin-1 is involved in adaptive mechanisms in adipose tissue in obese subjects.

Clinical Trial Description

The investigator will define adaptive mechanisms in adipose tissue associated with galectin-1 in obese insulin-sensitive (Ob-IS) subjects compared with obese insulin-resistant (Ob-IR) subjects and lean healthy controls. Further, the investigator will study molecules secreted from adipose tissue that might trigger insulin secretion when blood glucose is normal. The investigator hypothesizes that Ob-IS subjects keep fatty acid levels normal through an adaptive response in adipose tissue that involves up-regulation of galectin-1 for dampening of immune cell activity and stimulation of lipolysis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06065930
Study type Observational
Source Vastra Gotaland Region
Contact Per-Anders E Jansson, Prof
Phone 46 70 203 30 10
Email per-anders.jansson@wlab.gu.se
Status Recruiting
Phase
Start date May 5, 2023
Completion date December 31, 2028
View Details
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