Exercise Training and Insulin Sensitivity

Obesity Clinical Trial

Official title:

Exercise Training and Adipose Tissue Insulin Sensitivity

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05930834
• Other study ID #: 2096068
• Status: Not yet recruiting
• Phase: N/A
• Start date: July 2024
• Est. completion date: December 2025

Study information

• Verified date: December 2023
• Source: University of Missouri-Columbia
• Contact: Alan Maloney, MS
• Phone: 989-954-3366
• Email: amzdr[@]mail.missouri.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Regular exercise participation is known to reduce cardiometabolic disease risk but the impact that exercise training has on adipose tissue (AT) metabolism is poorly understood, particularly in humans. It is well established that exercise training improves whole-body glucose levels and increases insulin sensitivity, and this can occur within one or two weeks. These effects are usually due to adaptations in skeletal muscle, the tissue responsible for the majority of glucose disposal. However, many studies have now determined that exercise training also results in adaptations in AT that improve whole-body metabolic health by improving glucose uptake into the AT.

Skeletal muscle is thought to account for approximately 75-85% of glucose uptake , and this process is impaired in .individuals who are insulin-resistant state. It is postulated that the increased level of adiposity that accompanies severe obesity would result in higher dependency on AT for glucose uptake as the AT would be a bigger "sink". Thus the role of AT in inducing whole body insulin resistance is still unclear, particularly in individuals with obesity.

This study will examine the changes in AT glucose uptake before and after 4 weeks of exercise training in obese individuals and establish if there are sex differences.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 24
• Est. completion date: December 2025
• Est. primary completion date: October 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 21 Years to 45 Years

Eligibility

Inclusion Criteria:

• non-smokers, weight stable (<4 kg) within the last 6 months will be recruited for this study.

• sedentary (not engaged in planned physical activities and performing less than a total of 2 h of physical activity per week during the last 6 months) men and women whose BMI is classified as obese (>30 kg/m2).

Exclusion Criteria:

• cardiovascular disease, uncontrolled hypertension (no beta blockers), smokers, pregnant, have any recent changes in hormonal birth control, or on any medications known to impact metabolism.

• All participants will be regular sleepers with a duration of 7-9 hours/night.

• Subjects with orthopedic limitations will not be included.

Related Conditions & MeSH terms

• Exercise
• Insulin Resistance
• Obesity

Intervention

Behavioral:
• exercise
All subjects will undergo exercise training for 4 wks. 45-60 min of exercise, 4 sessions/wk supervised, 1 session unsupervised. intensity 60% of VO2 max

Locations

Country	Name	City	State
United States	University of Misouri	Columbia	Missouri

Sponsors (1)

Lead Sponsor	Collaborator
University of Missouri-Columbia

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	GLUT4 protein expression	protein expression	4 weeks
Primary	TB1CD4 protein expression	TB1CD4 protein expression	4 weeks
Secondary	percent body fat	Body fat will be measured using DEXA pre and post training	4 weeks