Exercise-Induced Gut Permeability in Normal-weight Obesity

Obesity Clinical Trial

Official title: Indicators of Gut Permeability in Normal-weight Obesity in Response to Brief, Maximal and Sustained, Submaximal Exercise

Status Recruiting

Clinical Trial Summary

Exercise acutely increases gut permeability and inflammation, even in healthy populations. However, whether this response differs in groups at-risk for CVD that present with low-grade inflammation (e.g., normal-weight obesity) has yet to be examined. The investigators aim to measure serum indicators of gut permeability in those with normal-weight obesity pre- and post-short, intense exercise and sustained, moderate exercise

Clinical Trial Description

The investigator's overall goal is to examine how indicators of gut permeability change in response to exercise in individuals with normal-weight obesity (i.e., normal body mass index [BMI] and high body fat percent) relative to those with a normal BMI and low body fat percent and those with a BMI in the obesity range and high body fat percent.

The investigators will examine indicators of gut permeability (specified in primary outcomes) in response to a short, intense bout of exercise (i.e., VO2 max test on a cycle ergometer) and sustained, moderate bout of exercise (i.e., 45 minutes at 65% measured VO2 max on a cycle ergometer).

Additionally, the investigators will measure basic anthropometrics, blood lipids and glucose, and body composition with DXA. ;

Related Conditions & MeSH terms

• Body Weight
• Obesity

• NCT number: NCT05889767
• Study type: Interventional
• Source: Oklahoma State University
• Contact: Bryant H Keirns, MS
• Phone: 3166891711
• Email: bryant.keirns@okstate.edu
• Status: Recruiting
• Phase: N/A
• Start date: January 10, 2023
• Completion date: August 1, 2023