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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05759637
Other study ID # 05J101
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date May 6, 2022
Est. completion date May 6, 2024

Study information

Verified date March 2023
Source Istituto Auxologico Italiano
Contact Valentina Morelli, PhD
Phone 02619112547
Email v.morelli@auxologico.it
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The present observational cross-sectional study is aimed to assess: the hidden hypercortisolism (HidHyCo) prevalence in a sample of Type 2 diabetes (T2D) patients and the clinical characteristics more frequently associated with the HidHyCo presence and the HidHyCo prevalence in an adequate sample of obese patients without T2D and the clinical characteristics more frequently associated with the HidHyCo presence.


Description:

Mild and asymptomatic hypercortisolism has been described to be associated with increased prevalence of chronic complications of cortisol excess, such as osteoporosis, hypertension, type 2 diabetes (T2D) and obesity and with increased mortality. In patients with osteoporosis, hypertension, T2D or obesity, this form of hypercortisolism may remain occult (hidden hypercortisolism, HidHyCo), until its presence is suspected on the basis of particular characteristics of the underlying diseases. The HidHyCo prevalence in the general population is estimated to be 0.2-2%, but it has been suggested to be even higher (up to 10%) in some specific populations as for example in patients T2D. Data regarding the prevalence of HidHyCo in obese populations are limited, Therefore, the issue of which diabetic or obese patient has to be screened for HidHyCo has recently become a widely debated topic. Therefore, the aims of the present study protocol are to assess: i) the HidHyCo prevalence in a sample of T2D patients and the clinical characteristics more frequently associated with the HidHyCo presence; ii) the HidHyCo prevalence in an adequate sample of obese patients without T2D and the clinical characteristics more frequently associated with the HidHyCo presence. All T2D and obese-without T2D patients between 18 and 75 years of age, consecutively referred to the out-patient clinics for Diabetes and Obesity of our center will be assessed for possible inclusion. At the enrolment in all patients anthropometric e biochemical variables will be recorded. At the enrolment we will evaluate cortisol levels after dexamethasone suppression test (F-1mgDST) in all T2D and obese-without T2D patients, who have been included in the study and who have given the informed consent to participate in the study. In all subjects with F-1mgDST >1.8 μg/dL, cortisol levels after two-day low dose (2 mg/day) dexamethasone suppression test (F-2mgx2dDST) will be performed. Patients with F-2mgx2dDST above >1.8 μg/dL will be considered affected with possible HidHyCo and will be studied following the available guidelines for the diagnosis of hypercortisolism.


Recruitment information / eligibility

Status Recruiting
Enrollment 3200
Est. completion date May 6, 2024
Est. primary completion date May 6, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years to 75 Years
Eligibility Inclusion Criteria: patients with T2D and Obesity Exclusion Criteria: - pregnancy/breast feeding, - sleep apnea, - prepuberal onset of hypertension, hormonal hypersecreting adrenal mass, - symptoms of hypercortisolism; - already known secondary hypertension; - conditions associated with increased hypothalamic-pituitary-adrenal (HPA) axis activity, -severe autoimmune/rheumatologic and hematologic diseases, alcoholism, kidney disease (glomerular filtration rate <60) - drugs influencing the HPA axis activity. For inclusion in Group 2 the presence of T2D will be an exclusion criteria

Study Design


Intervention

Diagnostic Test:
1mg DST
measurement of cortisol levels after 1 mg of dexamethasone (DST) at 11 pm

Locations

Country Name City State
Italy Istituto Auxologico Italiano Milan

Sponsors (1)

Lead Sponsor Collaborator
Istituto Auxologico Italiano

Country where clinical trial is conducted

Italy, 

Outcome

Type Measure Description Time frame Safety issue
Primary Hidden Hypercortisolism prevalence in a sample of T2D patients prevalence of patients with F-1mgDST>1.8 mcg/dl 24 months
Primary Hidden Hypercortisolism prevalence in a sample of Obese patients prevalence of patients with F-1mgDST>1.8 mcg/dl 24 months
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