Obesity Clinical Trial
— ParadoxOfficial title:
Association of Obesity and Cardiovascular Outcomes in Patients With Dilated Cardiomyopathy : a Korean Nationwide Cohort Study
In this study, the investigators evaluated the association between various measures of adiposity [BMI and waist circumference (WC)] and clinical outcomes in Asian patients with dilated cardimyopathy, using a nationwide population based cohort.
Status | Recruiting |
Enrollment | 30000 |
Est. completion date | December 31, 2024 |
Est. primary completion date | October 31, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 20 Years and older |
Eligibility | Inclusion Criteria: - Patients newly diagnosed with DCMP between January 2015 and December 2020. Exclusion Criteria: - Patients aged <20 years - Patients already diagnosed with DCMP before 2015 - Patients with coronary artery disease, valvular heart disease, congenital heart disease, hypothyroidism, hyperthyroidism, and the cancer |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Ajou University School of Medicine | Suwon | Gyeong-gido |
Lead Sponsor | Collaborator |
---|---|
Ajou University School of Medicine |
Korea, Republic of,
Castleberry CD, Jefferies JL, Shi L, Wilkinson JD, Towbin JA, Harrison RW, Rossano JW, Pahl E, Lee TM, Addonizio LJ, Everitt MD, Godown J, Mahgerefteh J, Rusconi P, Canter CE, Colan SD, Kantor PF, Razoky H, Lipshultz SE, Miller TL. No Obesity Paradox in Pediatric Patients With Dilated Cardiomyopathy. JACC Heart Fail. 2018 Mar;6(3):222-230. doi: 10.1016/j.jchf.2017.11.015. Epub 2018 Feb 7. — View Citation
Kim MS, Kim WJ, Khera AV, Kim JY, Yon DK, Lee SW, Shin JI, Won HH. Association between adiposity and cardiovascular outcomes: an umbrella review and meta-analysis of observational and Mendelian randomization studies. Eur Heart J. 2021 Sep 7;42(34):3388-3403. doi: 10.1093/eurheartj/ehab454. — View Citation
Rayner JJ, Peterzan MA, Clarke WT, Rodgers CT, Neubauer S, Rider OJ. Obesity modifies the energetic phenotype of dilated cardiomyopathy. Eur Heart J. 2021 Sep 20;43(9):868-77. doi: 10.1093/eurheartj/ehab663. Online ahead of print. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Composite of Outcomes | Death + CV hospitalization + Fatal arrest event | 5 years | |
Secondary | Death | Mortality | 5 years | |
Secondary | CV hospitalization | Admission caused by Cardiovacular disease | 5 years | |
Secondary | Fatal arrest event | Event of cardiac arrest by ventricular tachycardia and fibrillation | 5 years |
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