Obesity Clinical Trial
Official title:
Effects of Multicomponent Training on Inflammation Parameters in Correlation With Muscle Quality and Function in Elderly Obese Woman
Population aging worldwide has increased substantially in recent years. In order to prevent disabling diseases and improve the quality of life, it is necessary to understand the conditions related to the health of this specific population. One of the known alterations that occur in the body is the increased low-grade systemic inflammatory process, anabolic resistance, and muscle catabolism. These conditions can negatively interfere with muscle quality and functionality. However, the maintenance of the metabolic and physical functionality of muscle tissue can be preserved by performing physical exercises throughout life because of its anti-inflammatory mechanisms. In the present study, a multicomponent training program that combines aerobic, strength, balance, and flexibility capacities was used. The hypothesis is that performing this type of physical exercise will mitigate meta-inflammation and its negative effects, in addition to stimulating anabolic signals and reducing insulin resistance present in anabolic resistance, leading to improved quality and muscle functionality in elderly women with obesity.
Status | Recruiting |
Enrollment | 38 |
Est. completion date | December 30, 2022 |
Est. primary completion date | November 1, 2022 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 60 Years to 75 Years |
Eligibility | Inclusion Criteria: - BMI between 30 and 40kg/m²; Exclusion Criteria: - alcoholics - smokers - diseases that prevents the practice of physical activity - medical impediment to the practice of physical exercise throughout the study - infectious diseases - coronary diseases - chronic kidney diseases - chronic use of corticosteroids - chronic use of immunomodulators - undergoing nutritional monitoring or weight loss treatment - score =13 for cognitive screening on the Mini-Mental State Examination (MMSE) |
Country | Name | City | State |
---|---|---|---|
Brazil | University of São Paulo, School of Physical Education and Sports of Ribeirão Preto | Ribeirão Preto | Sp |
Lead Sponsor | Collaborator |
---|---|
University of Sao Paulo |
Brazil,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes in inflamatory markers | Evaluate the inflamatory markers PCR, IL-1ß, IL-6, IL-10, IL-15, TNF-a, NF?ß, NLRP3, myonectin, SIRT1, sTNFR1, IL-10, IL-13, adiponectin | 12 weeks | |
Primary | Changes in muscle quality | Evaluate the quantity of intramuscular fat deposits trough ultrasound pre and post intervention | 12 weeks | |
Secondary | Changes in muscle function | Evaluate the muscle function trough the load test pre and post intervention | 12 weeks | |
Secondary | Changes in metabolic parameters - fasting blood glucose | Changes in fasting blood glucose samples in pre and post intervention | 12 weeks | |
Secondary | Changes in metabolic parameters - insulin sensitivity | Changes in insulin sensitivity, estimated through HOMA-IR pre and post intervention | 12 weeks | |
Secondary | Changes in muscle remodeling peptides | Changes in PNPLA3 and PNP3 in blood samples in pre and post intervention | 12 weeks | |
Secondary | Body composition changes | Changes in fat-free mass and fat mass evaluated pre and post intervention by iDEXA | 12 weeks | |
Secondary | Changes of physical performance | Physical performance changes, evaluated through physical tests. | 12 weeks | |
Secondary | Changes in blood myostatin | Changes in blood myostatin levels pre and post intervention | 12 weeks | |
Secondary | Indirect calorimetry assessment | Changes in resting metabolic rate (RMR) evaluated pre and post intervention by indirect calorimetry | 12 weeks | |
Secondary | Changes in metabolic parameters - lipid profile | Changes in lipid profile (total cholesterol, HDL-c, LDL-c, triglycerides)samples in pre and post intervention | 12 weeks |
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