Obesity Clinical Trial
Official title:
Can the Betatrophin be a Reliable Marker of Insulin Resistance in Normal Weight and Overweight Women With Polycystic Ovary Syndrome?
This is an original study giving an information about the association body mass index, polycystic ovary syndrome and betatrophin.
Introduction: Betatrophin is a protein hormone which has a significant role in glucose
homeostasis and lipid metabolism. The aim of this study is to compare the levels of serum
betatrophin in overweight and normal weight women with PCOS.
Material and Method: Thirty-five patients normal weight women with PCOS (BMI<25) and 38 obese
women with PCOS (BMI≥25) were included in this prospective, cross-sectional study. Patients
were selected according to Rotterdam criteria. Serum betatrophin levels were studied by ELISA
method and then compared between these two groups besides the following additional parameters
as waist circumference/hip circumference ratio, fasting blood glucose, 75 g OGTT (oral
glucose tolerance test) results and HOMA-IR levels.
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