Effect of Meal Texture on Glucose-metabolism and Gut Hormone Response After Bariatric Surgery

Obesity Clinical Trial

— Obesity  

Official title:

Does Meal Texture Have Different Impact on Glucose Metabolism and Intestinal Hormone Response After Gastric Bypass and Sleeve Gastrectomy Operated Patients?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04082923
• Other study ID #: H-19027100
• Status: Completed
• Phase: N/A
• Start date: October 3, 2019
• Est. completion date: May 1, 2021

Study information

• Verified date: August 2021
• Source: Hvidovre University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators want to evaluate the difference in glucose metabolism and intestinal hormonal response after a liquid meal versus a solid meal in patients after bariatric surgery.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 36
• Est. completion date: May 1, 2021
• Est. primary completion date: December 1, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age > 18 years

• RYGB or SG operation > 12 months prior to inclusion

• Weight stable (± 3 kg during the last month)

• HbA1c < 48 mmol/mol before surgery, and no history of diabetes

• HbA1c < 48 mmol/mol and fasting plasma glucose < 6.1 mmol/l at inclusion

Exclusion Criteria:

• Thyrotoxicosis or inadequately treated hypothyreosis

• Hemoglobin < 6.5 mmol/l at inclusion

• Pregnancy or breast feeding

• Medication affecting the planned examinations

Related Conditions & MeSH terms

• Gastric Bypass
• Glucose Metabolism Disorders
• Gut Hormones
• Metabolic Diseases
• Obesity
• Sleeve Gastrectomy

Intervention

Other:
• Liquid meal
Four-hour liquid mixed meal test
• Solid meal
Four-hour solid mixed meal test

Locations

Country	Name	City	State
Denmark	Department of Endocrinology, Hvidovre University Hospital	Copenhagen	Hvidovre

Sponsors (1)

Lead Sponsor	Collaborator
Hvidovre University Hospital

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	GLP-1 response	GLP-1 response after a liquid meal test compared to a solid meal test	240 minutes
Secondary	Difference in gut hormone response after bariatric surgery		240 minutes