Clinical Trial Details
— Status: Active, not recruiting
Administrative data
| NCT number |
NCT04028921 |
| Other study ID # |
STUDY00001808 |
| Secondary ID |
|
| Status |
Active, not recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
January 3, 2022 |
| Est. completion date |
June 30, 2024 |
Study information
| Verified date |
January 2024 |
| Source |
Children's Mercy Hospital Kansas City |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Our goal is to examine linkages between physical activity, appetite control, and energy
metabolism in adolescents. The investigators will assess metabolic function and appetite
control in male and female adolescents stratified by bodyweight and physical activity using
across-sectional study design.
Description:
Childhood obesity is the most serious public health problem of the 21st century, given the
prevalence, global reach, and widespread health, economic, and social consequences. While
weight gain at the most basic level is due to a chronic energy surplus, there are a host of
influences that act on the energy balance system that remain largely unknown. Thus, there is
a critical need to identify previously unexamined factors that may influence the energy
balance system in order to develop effective interventions for prevention and treatment. Our
long-term goal is to quantify the dynamic relationships between various physiological and
psychological components of the energy balance system. Our short-term goal is to examine
linkages between physical activity, appetite control, and energy metabolism in adolescents.
The status quo as it relates to appetite control is that body weight status and related
peripheral signals are a key regulator of energy intake. In contrast to body weight playing a
primary role in energy regulation, our working hypothesis is that high levels of regular
moderate-to-vigorous physical activity (MVPA) result in a metabolic phenotype consisting of
enhanced metabolic function and proper regulation of appetite, which prevents the development
of obesity. The investigators have reported that adults with low levels of MVPA have
dysregulated appetite control, evidenced by higher levels of energy intake and elevated
levels of dietary disinhibition. Additionally, the investigators have observed that rats with
low fitness possess dysregulated control of appetite and reduced hepatic fat oxidation
compared to rats with high fitness. Based on these findings in adults and rodents, in
addition to supportive work by others, the investigators hypothesize that low levels of MVPA
create a metabolic phenotype, leading to dysregulated appetite control which predisposes
individuals to weight gain. To test this hypothesis the investigators will perform a study
focused on the links between physical activity and appetite. The investigators will assess
metabolic function and appetite control in male and female adolescents stratified by
bodyweight (normal vs overweight/obese) and physical activity (sedentary vs. active) using a
2 x 2 cross-sectional study design (N=44). The specific aim of the proposed study is: 1) To
examine the association between physical activity and appetite control in adolescents, with
metabolic function serving as a mediator. At the completion of the study, it is our
expectation that the investigators will have described the independent effects of physical
activity and body weight on energy metabolism and appetite in adolescents. This study will
have a significant positive impact on the understanding of energy balance in adolescents, and
will inform public health interventions that specifically target mechanisms associated with
weight gain in youth.
