Obesity Clinical Trial
Official title:
Biphasic and Combined Effect of Aging & Obesity With Development of Effective Exercise Intervention Protocol
Obesity leads to a vicious circle that increases intramuscular fat, insulin resistance, promotes muscular dysfunction resulting in increased muscle fat accumulation. The study of muscle function and intramyocellular lipids is insufficient for obesity. Particularly, the study of mechanisms in muscle function and intramyocellular lipids is few nationally and internationally.
This study is prospective study. The goal of this study is
1. To examine the distribution and contractile properties (cross-sectional area, maximal
force, specific force, maximal shortening velocity) of single muscle fiber sex/Myosin
heavy chain (MHC) type-related differences, by extracting a single muscle fiber from the
vastus lateralis in young men and women.
2. To examine the effects of intramyocellular lipids on physical activity ability, muscle
dysfunction, and metabolic disorders in relation to aging and obesity.
3. To examine the effects of intramyocellular lipids on physical activity ability, muscular
dysfunction, and metabolic disorders after 12 weeks resistance exercise intervention.
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