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Effect of Aging & Obesity With Exercise Intervention

Obesity Clinical Trial

Official title:
Biphasic and Combined Effect of Aging & Obesity With Development of Effective Exercise Intervention Protocol

Clinical Trial Summary

Obesity leads to a vicious circle that increases intramuscular fat, insulin resistance, promotes muscular dysfunction resulting in increased muscle fat accumulation. The study of muscle function and intramyocellular lipids is insufficient for obesity. Particularly, the study of mechanisms in muscle function and intramyocellular lipids is few nationally and internationally.

Clinical Trial Description

This study is prospective study. The goal of this study is

1. To examine the distribution and contractile properties (cross-sectional area, maximal force, specific force, maximal shortening velocity) of single muscle fiber sex/Myosin heavy chain (MHC) type-related differences, by extracting a single muscle fiber from the vastus lateralis in young men and women.

2. To examine the effects of intramyocellular lipids on physical activity ability, muscle dysfunction, and metabolic disorders in relation to aging and obesity.

3. To examine the effects of intramyocellular lipids on physical activity ability, muscular dysfunction, and metabolic disorders after 12 weeks resistance exercise intervention. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03951857
Study type Interventional
Source Seoul National University Bundang Hospital
Contact
Status Completed
Phase N/A
Start date November 18, 2016
Completion date February 29, 2020
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