Obesity Clinical Trial
Official title:
Einfluss Von Hochkalorischer Nahrungsaufnahme Auf Die Insulinsensitivität Des Menschlichen Zentralnervensystems
Obesity if known to be associated with brain insulin resistance in humans and evidence is
rapidly accumulating that brain insulin resistance influences peripheral metabolism, eating
behavior and cognition. A reduced insulin response in the brain is found mainly in people
with a metabolically unfavorable fat distribution - high visceral fat. Visceral fat produces
inflammatory mediators and elevated inflammatory levels are closely linked to insulin
resistance. Inflammation of the brain (i.e., neuroinflammation) has been proposed as a
possible cause of brain insulin resistance. Interestingly, rodent models of a high calorie
diet show that these inflammatory mechanisms occur rapidly in the brain, even prior to weight
gain of the animals. Among other things, it has been shown in humans that a short-term
increase in calories, especially carbohydrates and fats, reduces insulin sensitivity in the
body and increases inflammatory parameters in the blood. Whether a high-calorie diet triggers
insulin resistance or inflammation in the human brain is currently unknown.
Aim of study:
The aim of the study is to investigate the effects of a five-day high calorie diet in healthy
young male volunteers on peripheral and brain insulin sensitivity as well as on eating
behavior, mood and cognition. Brain insulin sensitivity, peripheral metabolism and different
behavioral assessments will be evaluated before, 1 week and 2 weeks after high caloric diet.
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