Chronic Effects of Fats on Satiety & Energy Needs

Obesity Clinical Trial

Official title:

Chronic Effects of Fats on Satiety and Energy Expenditure

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT03236181
• Other study ID #: GFHNRC509
• Status: Terminated
• Phase: N/A
• Start date: October 3, 2017
• Est. completion date: May 24, 2018

Study information

• Verified date: August 2018
• Source: USDA Grand Forks Human Nutrition Research Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the effect of dietary fat on satiety (the experience of fullness between one meal and the next) and energy metabolism over an extended period of time (chronic effects). How dietary fat sources affect satiety, appetite and energy use is unclear. The investigators will use a controlled setting for the studies. They want to know if the source of dietary fat alters satiety, satiety hormones, and energy expenditure responses after consuming different diets.

Description:

This work will address the interaction of obesity and dietary fatty acids in regulating satiety and energy metabolism. The primary objective is to determine the effects of chronic intake of dietary fatty acids of varied saturation and chain length on satiety, thermogenesis and energy utilization in healthy individuals. The investigators hypothesize that unsaturated fatty acids will 1) increase satiety and 2) increase energy metabolism and that 3) the fatty acid binding protein polymorphisms are associated with reduced energy expenditure in response to dietary fat intake.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 1
• Est. completion date: May 24, 2018
• Est. primary completion date: May 24, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 55 Years

Eligibility

Inclusion Criteria:

• body mass index between 25.0-34.9 kg/m2

• free of major diagnosed, untreated medical conditions

• non-smoking or use of other tobacco products, including e-cigarettes

• not taking steroid-based medications

• not planning to or currently attempting to gain or lose weight

• willing to comply with study demands

• low intake of long chain omega-3 fatty acids (<0.10 g/d) or willing to reduce intake for 6 weeks prior to starting the study

Exclusion Criteria:

• diagnosed eating disorders

• diabetes (blood sugar = 126 mg/dl)

• hypertension (systolic > 160 mmHg or diastolic > 100 mmHg)

• diagnosed cardiovascular, pulmonary, skeletal and metabolic diseases

• currently pregnant or planning to become pregnant, or lactating

• taking medications known to affect appetite, blood lipids, body composition, body weight, or food intake (appetite control drugs, steroids, antidepressants)

Related Conditions & MeSH terms

• Obesity
• Overweight

Intervention

Other:
• SFA
High saturated fatty acid/SFA oil source
• MUFA
High monounsaturated fatty acid/MUFA oil source
• PUFA
High polyunsaturated fatty acid (linoleic)/PUFA oil source
• LCn3
High polyunsaturated fatty acid (omega-3)/LCn3 oil source

Locations

Country	Name	City	State
United States	USDA Grand Forks Human Nutrition Research Center	Grand Forks	North Dakota

Sponsors (1)

Lead Sponsor	Collaborator
USDA Grand Forks Human Nutrition Research Center

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Acute effect of fat intake on energy expenditure as determined by metabolic rate		Incremental Area Under the Curve (iAUC) of metabolic rate from 0 to 4 hours