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Study on Mechanisms of Changes in Liver Disease and Sex Steroid Metabolism During Weight Loss — SMELSS  

Obesity Clinical Trial

Official title:
Study on Mechanisms of Changes in Liver Disease and Sex Steroid Metabolism During Weight Loss

Clinical Trial Summary

The main objective of the study is to gain insight in the early dynamics and mechanisms of recovery of liver disease and sex steroid metabolism during weight loss in obese men and women and to investigate whether surgical weight loss has differential effects as compared to weight loss with life style measures. In addition, we want to evaluate the postprandial hypoglycemic reactive syndrome (PPHRS) in these patients using a standard chewable meal. Secondary objectives are investigating determinants for the changes in sex steroids, liver disease and PPHRS. Possible determinants to be investigated are adipocytokine secretion patterns, body composition, resting metabolism rate, weight loss per se and changes in fat distribution, parameters of fatty acid metabolism, … .

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02964780
Study type Observational
Source University Ghent
Contact
Status Completed
Phase
Start date January 19, 2016
Completion date May 5, 2020
View Details
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