Obesity Clinical Trial
Official title:
Antibiotic-related Serious Adverse Events in Obese Patients Treated for Bone and Joint Infection
It exists recommendations to get an optimal antibiotic treatment for bone and joint
infection and prescription of antibiotics in the bone and joint infections on material meets
certain obligations: the micro-organism must be known, the antibiotic therapy must be
started in association, obtaining high plasma levels, use of molecules having good bone
circulation. It is recommended to initially administer treatment with intravenous route and
to propose an oral relay, under conditions. It is recommended to administer the antibiotic
treatment for at least 6 weeks.
The dosages of antibiotics are adapted to the weight of patients in order to respond to
those recommendations. But little is known about the optimal dose of treatment to give to
obese patients (BMI>=30) and the frequency of serious adverse events in these patients in
which the dosage is then higher can be more important compared to non-obese patients. The
aim of the study is then to evaluate the risk of occurrence of serious adverse events in
obese patients and to identify risks factors.
This study consists in a retrospective cohort of obese patients treated for a bone or joint
infection and having had a serious adverse event. Several data are collected concerning:
demographics data, treatment responsible of the serious adverse event (molecules, dosage,
route), description of the serious adverse event, residual rate for vancomycin.
n/a
Observational Model: Cohort, Time Perspective: Retrospective
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