Obesity Clinical Trial
Official title:
Effect of GLP-1 Receptor (GLP-1R) Agonists on Cardiac Function and on Epicardial Adipose Tissue (EAT) Volume and on Myocardial TG Content in Obese Diabetics
Glucagon-like peptide-1 (GLP-1) receptor agonist are new treatment of type 2 diabetes, they
lower blood glucose level (by enhancement of glucose-dependent insulin secretion and
suppression of excess glucagon secretion) and reduce weight by inducing satiety and slowing
of gastric emptying. Beneficial effects of GLP-1 and GLP-1 receptor (GLP-1R) agonists on
cardiovascular function have been suggested. They improve biomarkers of CV risk, decrease
systolic blood pressure, improve endothelial function and have beneficial effects on
myocardium. Nevertheless, few studies have analysed the effect of GLP1 treatment on
myocardial function in type 2 obese diabetic.
Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes
mellitus. It was recently shown that 16 weeks of caloric restriction in obese patients with
diabetes decrease myocardial triglyceride content and improve myocardial function (cardiac
output, normalized stroke volume, LV mass and normalized end diastolic volume), and
diastolic function. However, no study has evaluated the impact of Glucagon-like peptide-1
(GLP-1) receptor agonist in obese diabetics on myocardial TG content.
Recent studies have suggested that increased epicardial adipose tissue (EAT) could be an
important risk factor for cardiac diseases. We and others have already evidenced a
correlation between the volume of epicardial adipose tissue and the presence or the severity
of coronaropathy. The impact of weight loss on the volume of EAT or the characteristics of
EAT is mostly unknown.
n/a
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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