Obesity Clinical Trial
Official title:
Structured Exerise Training in Infertile Obese Patients Treated With Assisted Reproductive Techniques: a Randomized Controlled Trial
Obese women experience increased infertility rate and longer time to conception showing
lower pregnancy and live-birth rates both in natural and assisted conceptions. Body weight
loss improves not only spontaneous pregnancy rates but also those of assisted reproductive
techniques (ARTs). Almost all studies refer to body weight loss due to lifestyle
intervention programs consisting in hypocaloric diet and increased physical activity,
whereas very little is known about the specific effects of physical activity alone on human
reproduction.
In a previous retrospective study, we demonstrated that physical activity enhances the
reproductive performance of obese infertile patients who receive in vitro fertilization
(IVF) and intracytoplasmic sperm injection (ICSI) cycles, regardless of body weight loss.
The aim of this randomized controlled trial (RCT) will be to evaluate if a structured
exercise program improve the effectiveness of ARTs.
Women with primary infertility scheduled to an IVF/ICSI procedure, obese and with a stable
BMI will be randomized to receive a structured exercise program or nothing.
Patients will undergo a gonadotropin ovarian hyperstimulation for standard IVF/ICSI
procedure.
clinical and biological data will be evaluated in each subject.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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