Obesity Clinical Trial
Official title:
The Effects of Long-term Arabinoxylan Administration on Intestinal Barrier Function and Innate Immunity
The higher prevalence of overweight and obesity among the population contributes to
increased incidences of chronic metabolic diseases. Obesity is considered a low-grade
systemic inflammatory condition through 1) production of pro-inflammatory cytokines by
adipose tissue and 2) alterations in intestinal microbiota composition and associated
increase in intestinal permeability. Healthcare costs related to these diseases are rising;
prevention or delay of onset of disorders associated with overweight is needed.
Administration of wheat arabinoxylans (NAXUS), a non-digestible carbohydrate, may change the
intestinal microbiota composition and have beneficial effects on gut epithelial barrier,
especially on permeability and innate immune function.
Objective: To assess the effects of NAXUS on intestinal barrier function, immune system
performance and metabolic control. Prebiotic properties of NAXUS will be studied. Tolerance
of the product in different doses will also be investigated.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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