Clinical Trials Logo

Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT01828372
Other study ID # KPUK-12-GenPOPPK-2
Secondary ID 2013-000779-33
Status Not yet recruiting
Phase N/A
First received March 14, 2013
Last updated April 5, 2013
Start date May 2013
Est. completion date March 2017

Study information

Verified date April 2013
Source University of Cologne
Contact Uwe Fuhr, Professor
Phone 0049-221-478
Email uwe.fuhr@uk-koeln.de
Is FDA regulated No
Health authority Germany: Federal Institute for Drugs and Medical Devices
Study type Interventional

Clinical Trial Summary

The study includes two study parts in which blood is collected from the patients.

Study part A (observational study, already received positive ethics committee vote; Our sign: 12-330): Use of blood samples gathered during routine blood withdrawal Study part B (interventional study in the sense of additional blood samples but without an investigational product): Optional, for further pharmacokinetic questions: blood withdrawal with a maximum of 20 ml ( ten tubes of 2 ml each) within a maximal study length of four weeks.

The primary objective of this study is to gain an overview about drug concentrations in plasma and/or cerebrospinal fluid (CSF), in order to determine pharmacokinetics of drugs in patients. Any drug may be tested, however the initial focus is on antiinfective, antineoplastic, and antipsychotic drugs.

Many published studies show that there is a profound lack of information on pharmacokinetics and interactions of many commonly used drugs in clinical routine, and that drug concentrations, if controlled by therapeutic drug monitoring, are not in the therapeutic range (provided that such ranges are known at all).


Description:

For an effective pharmacotherapy in patients with different demographic characteristics (age, weight or lean body mass), there is often a lack of information on the dosage of drugs.

The predictability of the action of a drug is additionally impaired by genetic predisposition. Even if the effect of genetic variants has been demonstrated, the respective characteristic for the patient is usually not known.

For example, a study (Gamelin et al., 2008) of the "old" cytostatic drug 5-fluorouracil shows its genetically-dependent efficacy.

Only in about one third of patients does the concentration reach the desired therapeutic range (the dosage adjusted to body surface).

There is a significant lack of information on the pharmacokinetics, especially in critically ill patients.

These patients are excluded in modern drug approval studies, although it is anticipated that, depending on the drug, many patients with severely impaired renal function, renal replacement therapy, severe hepatic dysfunction, sepsis or multiple organ failure may later on obtain the substance.

This knowledge gap on the specific pharmacokinetics of drugs in selected populations is present not only for new drugs, but also for those that have already been used in therapy for decades.

Particularly for the effect of body weight and liver function on pharmacokinetics, data is very sparse. For the latter, the lack of data is particularly striking, when searching for data concerning patients with severe hepatic dysfunction. If occasional data for specific drugs are available, then for most substances these are not sufficient to develop a safe dosing regimen, e.g. for the aforementioned example of 5-fluorouracil. Furthermore, for many drugs reliable pharmacokinetic data in renal impairment or renal replacement therapy are not available. The available data is generally much better than in hepatic insufficiency, but especially the lack of data on the pharmacokinetics of metabolites in renal insufficiency may be of relevance, as such metabolites are active and play an important role for the effect, but they may also be responsible for side effects. To illustrate, the "Fachinformation" (as of April 30th 2012), the legally binding document for dosing issues of drugs in Germany, is attached. This table provides a selection of important drugs, while it is not exhaustive.

In hospitals predominantly severely ill patients are treated and several drugs are administered simultaneously. Thus, the issue of drug-drug interaction is in the center of attention. Unexpected new clinical interactions of drugs known for a long time, or interactions of well-known substances with new substances are reported. A recent example is an interaction caused by Cotrimoxazol, a drug combination used for decades (Antoniou et al., 2011).

In summary, it can be stated that in drug therapy there is a high demand for both the quantification of in vivo plasma and liquor drug concentrations and quantifying the effect of different characteristics on the pharmacokinetics of the drugs. Thus, concentrations for a broad range of substances which are used in the Cologne University Hospital should be measured, including their respective metabolites. Concentrations both in plasma and in CSF (for drugs supposed to have an effect on the central nervous system) will be quantified. This screening approach is possible due to the increasing availability of highly sensitive and selective liquid chromatography - tandem mass spectrometry (LC-MS/MS) methods, thereby the number of measurable substances markedly increased. The initial focus of our project is on the antiinfective, antineoplastic and antipsychotic agents.


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 1000
Est. completion date March 2017
Est. primary completion date April 2016
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Both genders are included.

- Patients willing and capable to confirm written consent prior to enrolment after ample information was given are eligible for the study.

Exclusion Criteria:

- In Study Part B patients with hemoglobin less 7 mg/dl or less 10 mg/dl including serious symptoms of anemia such as increased heart rate, shortness of breath, dizziness, weakness etc.

- The hemoglobin value must not be 10 days or older.

Study Design

Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening


Intervention

Other:
additional blood withdrawals
Blood withdrawals by either venous puncture or placement of permanent venous catheter.

Locations

Country Name City State
Germany Department of Pharmacology, Cologne University Hospital Cologne NRW

Sponsors (1)

Lead Sponsor Collaborator
University of Cologne

Country where clinical trial is conducted

Germany, 

Outcome

Type Measure Description Time frame Safety issue
Primary Pharmacokinetic Outcome Measures (e.g., Cmax, AUC) These assessments rely on multiple measurements over time and the Time Frame may include multiple time points describing the interval at which data are collected within four weeks after administration of drug of interest No
See also
  Status Clinical Trial Phase
Recruiting NCT04101669 - EndoBarrier System Pivotal Trial(Rev E v2) N/A
Recruiting NCT04243317 - Feasibility of a Sleep Improvement Intervention for Weight Loss and Its Maintenance in Sleep Impaired Obese Adults N/A
Terminated NCT03772886 - Reducing Cesarean Delivery Rate in Obese Patients Using the Peanut Ball N/A
Completed NCT03640442 - Modified Ramped Position for Intubation of Obese Females. N/A
Completed NCT04506996 - Monday-Focused Tailored Rapid Interactive Mobile Messaging for Weight Management 2 N/A
Recruiting NCT06019832 - Analysis of Stem and Non-Stem Tibial Component N/A
Active, not recruiting NCT05891834 - Study of INV-202 in Patients With Obesity and Metabolic Syndrome Phase 2
Active, not recruiting NCT05275959 - Beijing (Peking)---Myopia and Obesity Comorbidity Intervention (BMOCI) N/A
Recruiting NCT04575194 - Study of the Cardiometabolic Effects of Obesity Pharmacotherapy Phase 4
Completed NCT04513769 - Nutritious Eating With Soul at Rare Variety Cafe N/A
Withdrawn NCT03042897 - Exercise and Diet Intervention in Promoting Weight Loss in Obese Patients With Stage I Endometrial Cancer N/A
Completed NCT03644524 - Heat Therapy and Cardiometabolic Health in Obese Women N/A
Recruiting NCT05917873 - Metabolic Effects of Four-week Lactate-ketone Ester Supplementation N/A
Active, not recruiting NCT04353258 - Research Intervention to Support Healthy Eating and Exercise N/A
Completed NCT04507867 - Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III N/A
Recruiting NCT03227575 - Effects of Brisk Walking and Regular Intensity Exercise Interventions on Glycemic Control N/A
Completed NCT01870947 - Assisted Exercise in Obese Endometrial Cancer Patients N/A
Recruiting NCT06007404 - Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
Recruiting NCT05972564 - The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function Phase 1/Phase 2
Recruiting NCT05371496 - Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction Phase 2