Obesity Clinical Trial
Official title:
The Effects of 8 Weeks of Stretching Training on Arterial Stiffness, Wave Reflection, Endothelial Function and Cardiac Autonomic Control.
Hypertension is a major risk factor for cardiovascular disease. Hypertension and abdominal
obesity are associated with dysfunction of the main mechanisms of cardiovascular regulation,
the autonomic nervous system and the vascular endothelium. Increased sympathetic activity
and endothelial dysfunction are associated with increased arterial stiffness, which is an
independent risk factor for the development of hypertension and other cardiovascular
diseases. The recommended intervention for controlling BP in pre- and stage 1- hypertensive
individuals is lifestyle modifications such as exercise, and not drug therapy.Although
aerobic and resistance exercise has been shown to be beneficial for the cardiovascular
system, special populations such as the elderly and obese may have physical and/or
musculoskeletal limitations which may limit their participation in these exercise
modalities.
Stretching is a form of exercise that is widely recommended for injury prevention. Among the
benefits of stretching are an increased flexibility, enhanced muscular coordination, stress
relief, improved range of motion and an improved posture. Previous studies have shown
stretching training to increase arterial compliance and acutely increase sympathetic nerve
activity. In addition, low flexibility levels have been found to be associated with arterial
stiffness. Given that stretching of skeletal muscle causes an increase in sympathetic nerve
activity; repetitive stimulation of sympathetic activity induced by habitual stretching,
might chronically reduce resting sympathetic activity. The reduction in sympathetic activity
might result in a decrease of arterial stiffness and blood pressure.
The investigators hypothesis is that 8 weeks of stretching training would reduce arterial
stiffness, blood pressure and sympathetic activity in obese women. The investigators also
hypothesize that the improved arterial function with stretching would be associated with
increases in flexibility levels.
The purpose of this study is to examine the effects of 8 weeks of stretching training on
blood pressure,arterial stiffness, wave reflection, endothelial function and cardiovascular
autonomic control. The specific aim of the study is:
- To evaluate the effects of 8 weeks of ST on arterial function and aortic hemodynamics by
assessing arterial stiffness (aortic, systemic, and leg), aortic blood pressure and wave
reflection, and autonomic function (heart rate variability, vascular sympathetic activity
[low-frequency power of systolic BP variability], and baroreflex sensitivity)
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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