Effects of Monosodium Glutamate on Energy Balance and Eating Behavior

Obesity Clinical Trial

Official title:

Effects of Ingesting Monosodium Glutamate (MSG) on Energy Balance and Eating Behavior Following Moderate Energy Restriction and Weight Loss in Overweight Women

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01410838
• Other study ID #: WHNRC 222718-2
• Status: Completed
• Phase: N/A
• First received: August 3, 2011
• Last updated: May 19, 2015
• Start date: August 2011
• Est. completion date: August 2014

Study information

• Verified date: August 2014
• Source: USDA, Western Human Nutrition Research Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

This study will test whether regular consumption of Monosodium Glutamate (MSG) immediately prior to each of the three major meals (breakfast, lunch, dinner) inhibits body weight and fat regain following a period of moderate, yet clinically significant weight loss.

Description:

The proposed study enables us to assess the long term effects of consuming MSG on body weight regain following weight loss.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 44
• Est. completion date: August 2014
• Est. primary completion date: August 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 19 Years to 50 Years

Eligibility

Inclusion Criteria:

• Women

• Age 19-45

• BMI 27-35

• Blood pressure <140/90

• Non-smoking

Exclusion Criteria:

• Anemic: hgb < 11.5 mg/dL

• Sensitivity to MSG (self reported)

• Pregnant or planning to get pregnant

• Taking medication for hypertension, depression, or weight loss

• Diabetic

• Vegetarian

• MRI Contraindications: internal metal, braces on teeth, history of metal in the eye, claustrophobia

• blindness or heavily corrected vision

• not fluent in English

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Food Preferences
• Obesity
• Weight Gain

Intervention

Other:
• Broth
200 mL of sodium chloride containing broth, consumed three times per day
• Broth
200 mL of MSG containing broth consumed three times per day

Locations

Country	Name	City	State
United States	Western Human Nutrition Center, University of California Davis	Davis	California

Sponsors (2)

Lead Sponsor	Collaborator
USDA, Western Human Nutrition Research Center	Ajinomoto USA, INC.

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in body weight	Subjects will have their body weight measured to determine the effect of MSG on body weight regain following weight loss.	weeks 11, 12, and 25	No
Secondary	Change in body fat	Volunteers will have their body fat measured by DEXA (Dual X-ray Absorptiometry) to determine the effect of MSG on body fat regain following weight loss.	weeks 11 and 25	No
Secondary	Change in eating behavior	The effect of MSG on eating behavior will be measured using questionnaires, sensory evaluation testing, stress responsivity, and liking and wanting tests, and appetite assessments.	weeks 11, 12 and 25	No
Secondary	Change in resting energy expenditure	The effect of MSG on resting energy expenditure will be measured using respiratory gas exchange using a metabolic cart system.	weeks 11, 12, and 25	No

External Links

•   USDA Western Human Nutrition Research Center