Metabolic Fate Modifications of Saturated Fats After an Overfeeding

Obesity Clinical Trial

— SURNUT  

Official title:

Metabolic Fate Modifications of Saturated Fats After an Overfeeding

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00905892
• Other study ID #: CRNHRA-09-002
• Status: Completed
• Phase: N/A
• First received: May 20, 2009
• Last updated: June 22, 2011
• Start date: September 2005
• Est. completion date: March 2010

Study information

• Verified date: June 2011
• Source: Centre de Recherche en Nutrition Humaine Rhone-Alpe
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: Direction Générale de la Santé
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the partitioning of exogenous lipids in the postprandial period while a study of overfeeding. The method is based on the incorporation of a stable isotopic tracer (d31_palmitic acid, d31_C16) in lipoprotein triglycerides (TG-CHYLOMICRON and TG-VLDL) and in free fatty acids (FFA).

Description:

Healthy overweight and lean young men are subjected to an overfeeding during 56 days which corresponds to a supplement of 761 Kcal/day. During two exploration days (before : D0 et after : D56 overfeeding) they have ingested a breakfast with tracer (d31_palmitic acid, d31_C16, 20mg/kg) and blood and urine samples were collected every hour of each exploration day. The enrichment in deuterium was measured by gas chromatography-organic mass spectrometry (GC-OMS) in palmitic acid pool of lipid fractions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: March 2010
• Est. primary completion date: December 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• 18 to 55 years old

• BMI 18 to 30 kg/m²

• Stable physical activity

• Safety subject during medical consultation

Exclusion Criteria:

• Medical or surgical history which may affect energy expenditure (renal -cardiovascular -hepatic- endocrine-inflammatory diseases)

• Drug use that could affect energy expenditure (steroids, nicotine substitutes, thyroid hormones)

• Eating disorder

• Intensive sportive activity

• Subjects who Smoke

• Claustrophobic subjects

Study Design

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Inflammation
• Lipid Metabolism
• Obesity

Intervention

Dietary Supplement:
• Hyperlipidic overfeeding
100g per day of cheese + 40g per day of almonds + 20g per day of butter

Locations

Country	Name	City	State
France	Centre de recherche en nutrition humaine Rhone-Alpes	Pierre-Bénite

Sponsors (2)

Lead Sponsor	Collaborator
Centre de Recherche en Nutrition Humaine Rhone-Alpe	Institut National de la Santé Et de la Recherche Médicale, France

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Post prandial partitioning of exogenous lipids		Before and after overfeeding	No
Secondary	Genes expression in adipose and muscle tissues		Before and after overfeeding	No