Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose Tissue

Obesity Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00774488
• Other study ID #: GIP-Genexpression Study
• Status: Completed
• Phase: N/A
• First received: October 16, 2008
• Last updated: October 16, 2008
• Start date: January 2006
• Est. completion date: July 2007

Study information

• Verified date: October 2008
• Source: German Institute of Human Nutrition
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: Ethics Commission
• Study type: Interventional

Clinical Trial Summary

This clinical, randomized, cross-over study in obese healthy subjects aimed to analyse the acute effects of the incretin hormon Glucose Dependent Insulinotropic Polypeptide (GIP) on metabolic parameters and gene expression in subcutaneous adipose tissue.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 17
• Est. completion date: July 2007
• Est. primary completion date: July 2007
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• BMI > 28

• Healthy subjects

• Normal glucose tolerance

Exclusion Criteria:

• Diabetes,IFG, IGT

• Chronical-inflammatory diseases

• Hb < 12g/dl

• Elevation in liver enzymes or creatinin concentrations

• Great weight changes within last 12 months

• Any cancer diagnosis in last 10 years

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Insulin Sensitivity
• Metabolic Syndrome
• Metabolic Syndrome X
• Obesity

Intervention

Other:
• Glucose dependent insulinotropic polypeptide (GIP)
GIP-Infusions for 4 h in a postprandial concentration

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
German Institute of Human Nutrition	German Research Foundation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in gene expression of subcutaneous adipose tissue with microarray analysis		3 years	No
Secondary	Analysis of inflammatory marker (blood levels and gene expression), Activity of 11beta HSD and 11-beta HSD mRNA in adipose tissue, etc.		3 years	No