Effect of Weight Reduction on Inflammatory Markers and Genes Expression in Obese Individuals

Obesity Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00416156
• Other study ID #: TCVGH 05082
• Status: Completed
• Phase: N/A
• First received: December 25, 2006
• Last updated: December 26, 2006
• Start date: May 2005
• Est. completion date: November 2005

Study information

• Verified date: December 2006
• Source: Taichung Veterans General Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Interventional

Clinical Trial Summary

To investigate whether weight reduction by life style modification for 12 weeks will improve circulating inflammatory markers, adipocytokines as well as gene expression of proinflammatory protein obtained from circulating monocytes from obese individuals.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: November 2005
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 20 Years to 70 Years

Eligibility

Inclusion Criteria:

• Nondiabetes obese individuals with BMI greater than 27 kgs/m2

Exclusion Criteria:

• Diabetes

• Abnormal hepatic, renal and cardiac function

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Inflammation
• Obesity

Intervention

Behavioral:
• Lifestyle modification

Locations

Country	Name	City	State
Taiwan	Taichung Veterans General Hospital	Taichung

Sponsors (1)

Lead Sponsor	Collaborator
Taichung Veterans General Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Inflammatory responses after weight reduction
Secondary	BMI
Secondary	Circulating inflammatory markers
Secondary	Adipocytokines
Secondary	Gene Expression from mononuclear cells