Obesity Clinical Trial
The purpose of this study is to examine the consequences of lowering serum uric acid in
pre-hypertensive, obese adolescents pathways involved with how uric acid mediated
hypertension and renal disease. The specific aims are:
1. Test the hypothesis that lowering uric acid will improve endothelial function.
2. Test the hypothesis that lowering uric acid will reduce plasma renin activity and serum
angiotensin II levels.
3. Test the hypothesis that lowering uric acid will reduce markers of inflammation
Status | Completed |
Enrollment | 60 |
Est. completion date | January 2011 |
Est. primary completion date | January 2011 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 11 Years to 18 Years |
Eligibility |
Inclusion Criteria: Children between the ages of 11 and 18 body mass index greater than the 95th percentile for age Blood pressure between 75th and 95th percentile for age, gender and height percentile Exclusion Criteria: hypertension at the time of screening allergy to one of the study medications liver function abnormality (AST or ALT greater than twice the upper limit of normal for the laboratory) history of renal stones renal insufficiency (Schwartz formula calculated GFR less than 70ml per min per 1.73m2 BSA) positive urine pregnancy test diabetes organ transplant recipient currently treated with an angiotensin converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB), diuretic, other medications known to alter serum uric acid level lack of ability to comply with the study protocol |
Country | Name | City | State |
---|---|---|---|
United States | Texas Children's Hospital | Houston | Texas |
Lead Sponsor | Collaborator |
---|---|
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Baylor University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Casual BP | 3 months | ||
Secondary | 24- hour Ambulatory BP | 3 months | ||
Secondary | Systemic Vascular Resistance (measured by bioimpedance) | 3 months |
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