Obesity Clinical Trial
To conduct a genetic analysis of anatomic risk factors for sleep apnea in a well-characterized United States population-based registry of elderly male twins who have been successfully followed for the past 30 years.
BACKGROUND:
The contribution of genetic factors to sleep disorders has been demonstrated in twin and
family studies, and further understanding of the genetic underpinning of sleep disorders is
considered an important area of research. Many of the suggested risk factors for sleep apnea
(e.g.,craniofacial morphology, obesity) have genetic determinants. However, a formal genetic
analysis of these anatomical risk factors with sleep-recorded physiological measurements has
not so far been conducted.
DESIGN NARRATIVE:
The investigators recruited a subsample of pairs from the NAS-NRC World War II Twin Registry
in which at least one of the twin brothers reported sleep apnea symptoms and a subsample of
control pairs in which both twins reported no symptoms. They monitoring the subgroup of twin
pairs with overnight sleep recording. They also collected anthropometric measurements of
weight, height, neck circumference, and craniofacial morphology and blood samples for
determination of zygosity and DNA extraction for future molecular studies.
The twin design is most powerful for estimating the genetic and/or environmental overlap
between physiological measurements such as sleep-recorded disordered breathing, obesity, and
craniofacial morphology. The investigators chose to focus on an elderly male twin sample for
which a wealth of data relevant to this study had been previously collected. Twin pair
concordance or discordance for monitored sleep-disordered breathing allowed the full
characterization of genetic/familial and individual environmental factors associated with
the expression and severity of this condition.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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