Auditory Sensory Attenuation in Obesity

Obesity Clinical Trial

— Ud_SA_OB  

Official title:

The Sensory Attenuation Paradigm in Auditory Modality in Obesity

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT06298539
• Other study ID #: 21C308
• Status: Active, not recruiting
• Start date: March 1, 2023
• Est. completion date: December 31, 2024

Study information

• Verified date: March 2024
• Source: Istituto Auxologico Italiano
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The goal of this observational cross-sectional study is to test the sensory attenuation effect with auditory stimuli comparing women with obesity and healthy-weight women. Specifically, the study aims to test whether the sensory attenuation effect (i.e., the perceived loudness of a self-generated sound is weaker than when another person produces the same sound): i) is observed in obesity ii) it can be modulated in interactive action contexts, as was previously observed in healthy participants. Participants will compare the loudness of target sound with a comparison tone, which can be prompt by the participant by pressing a button on their own will (i.e., individual context) or upon the experimenter's signal (i.e., interactive context); externally-generated sounds are produced in the opposite way.

Description:

The perceived loudness of a self-generated sound is generally weaker than when another person produces the same sound. This effect is known as sensory attenuation, and it is considered a proof of sense of agency (i.e., it relies on the anticipation of the sensory-motor effects of one's intentional action). Recently, it was suggested that this effect is enhanced in interactive action contexts in healthy individuals, meaning that sounds are produced as a consequence of cooperation between individuals. Participants will compare the loudness of target sound with a comparison tone, which could be generated in 4 different conditions: i) participants press a button ii) the experimenter press the button iii) participants press the button upon the experimenter's signal (i.e., who touch the participants' arm) iv) the experimenter presses the button upon the participants' signal (i.e., who touch the experimenter's arm). However, it is not clear whether the same effect of cooperation can be observed also when individuals experience difficulties in social interactions and relationships. To this purpose, the study compared the sensory attenuation effect for auditory stimuli in a traditional (i.e., individual) and interactive context, comparing women with obesity and healthy-weight women. Indeed, relational difficulties and social withdrawal characterized this clinical condition.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 36
• Est. completion date: December 31, 2024
• Est. primary completion date: December 31, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• BMI > 30 kg/m2 (controls)
• handedness: right

Exclusion Criteria:

• history of eating disorders (controls)
• major psychiatric conditions (e.g., psychosis, personality disorders)
• developmental disorders (e.g., autism spectrum disorders)
• neurological or brain injuries disorders
• motor impairments

Related Conditions & MeSH terms

• Obesity

Locations

Country	Name	City	State
Italy	IRCCS Istituto Auxologico Italiano, San Giuseppe Hospital	Piancavallo	VCO

Sponsors (2)

Lead Sponsor	Collaborator
Istituto Auxologico Italiano	University of Turin, Italy

Country where clinical trial is conducted

Italy, 

References & Publications (2)

Scarpina F, Fossataro C, Sebastiano AR, Bruni F, Scacchi M, Mauro A, Garbarini F. Behavioural evidence of altered sensory attenuation in obesity. Q J Exp Psychol (Hove). 2022 Nov;75(11):2064-2072. doi: 10.1177/17470218211065766. Epub 2021 Dec 29. — View Citation

Weiss C, Herwig A, Schutz-Bosbach S. The self in social interactions: sensory attenuation of auditory action effects is stronger in interactions with others. PLoS One. 2011;6(7):e22723. doi: 10.1371/journal.pone.0022723. Epub 2011 Jul 27. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	point of subjective equality (PSE)	individual PSE in each experimental condition is obtained by fitting observed judgements of loudness, relative to seven possible comparison tones. The PSE represents the tone loudness that participants perceive as loud as the target sound (i.e., the sound intensity which records only 50% of correct judgments "which sounds was louder?")	day 1
Secondary	cognitive empathy	Interpersonal Reactivity Index - IRI: 28-item self-report questionnaire on a 5-point Likert scale (from 1 -does not describe me well to 5 - describes me very well). Four components of cognitive empathy are measured: i) perspective taking (IRI-PT); ii) fantasy (IRI-F); iii) empathic concern (IRI-EC); iv) personal distress (IRI-PD); each subscale includes 7 items (total scores range from 1 to 35): the higher the score, the higher the expression of cognitive empathy described in each subscale.	day 1
Secondary	interpersonal pleasure	Anticipatory and Consummatory Interpersonal Pleasure Scale - ACIPS: 17-item self-reported questionnaire scored on 6-point Likert scale (from 1 - very false for me to 6-very true for me). ACIPS total score ranges from 1 to 102: higher scores indicate higher anticipatory and consummatory interpersonal pleasure.	day 1