Obesity Clinical Trial
Official title:
The Effect of Liraglutide on Pancreatic Hormones and Its Size
Glucagon-like peptide-1 (GLP-1) is a gastrointestinal hormone used to treat type 2 diabetes
and severe overweight (Liraglutide).The two pancreas enzymes: amylase and lipase are slightly
elevated in GLP-1 treated compared with placebo-treated individuals. Increased levels of
these two enzymes (amylase and lipase) are associated with acute inflammation of the pancreas
(acute pancreatitis). In humans treated with GLP-1 (receptor agonist) there have not been
found an increased risk of acute pancreatitis.
Animal and cell studies have shown that the increased levels of amylase and lipase in the
blood are not due to an inflammatory state but adaptive changes (volume increase) of the
pancreas.
The investigators (professor Jens Juul Holst, professor Sten Madsbad) want to investigate
whether the increased levels of amylase and lipase in the blood of individuals treated with
the GLP-1 analogue Saxenda are due adaptive changes of the pancreas. This will be achieved by
measuring amylase and lipase before, during and after treatment with a GLP-1 receptor
agonist, and at the same time use advanced scanning equipment (PET-MR) from the Clinical
Physiological and Nuclear Medical Department at Rigshospitalet, which can determine any
volumetric changes in the pancreas with high reproducibility.
The scan will be centered on the pancreas, other organs are not evaluated why the study is
not designed to detect any malignant findings in the pancreas or other organs.
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