Obesity Clinical Trial
— PRIMEOfficial title:
Prebiotic Intervention to Improve Calcium Absorption After Gastric Bypass Surgery
Verified date | October 2020 |
Source | San Francisco Veterans Affairs Medical Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Gastric bypass surgery is a highly effective treatment for obesity, but it has negative effects on skeletal health, due in part to a dramatic decline in intestinal calcium absorption capacity. Animal and human studies suggest that non-digestible fibers termed prebiotics, such as soluble corn fiber (SCF), augment calcium absorption in the lower intestine as they act as substrates for beneficial gut microbiota. This is a pilot randomized controlled trial of the effects of SCF vs. placebo on intestinal calcium absorption, bone turnover marker levels, and the gut microbiome in postmenopausal women who have previously undergone gastric bypass surgery.
Status | Completed |
Enrollment | 20 |
Est. completion date | January 31, 2020 |
Est. primary completion date | January 31, 2020 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 75 Years |
Eligibility | Inclusion Criteria: 1. Postmenopausal women (no menses for =4 yrs) 2. = 75 yrs old, 3. Underwent Roux-en-Y gastric bypass surgery for weight loss 2-6 years prior Exclusion Criteria: 1. Serum 25(OH)vitamin D level <30 ng/mL (to remove the effect of vitamin D insufficiency/deficiency)* 2. History of >1 bariatric surgical procedure 3. Antibiotic therapy in the last 3 months 4. Regular pre- or probiotic use in the last 3 months 5. Regain of >50% of weight loss post-bypass 6. Calculated creatinine clearance <30 mL/min 7. Serum calcium >10.2 mg/dL 8. Use of hormone therapy, osteoporosis pharmacotherapy, glucocorticoids, or other medications impacting calcium metabolism 9. Thyroid stimulating hormone (TSH) <0.01 milli-international units per liter (mIU/L) A potential participant may be excluded if she has a condition or abnormality that in the opinion of the Investigator would compromise the safety of the participant or the quality of the data. *Women excluded due to 25(OH)D level will be offered re-screening after vitamin D supplementation. |
Country | Name | City | State |
---|---|---|---|
United States | UCSF | San Francisco | California |
Lead Sponsor | Collaborator |
---|---|
San Francisco Veterans Affairs Medical Center | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of California, San Francisco |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in fractional intestinal calcium absorption | Fractional calcium absorption to be determined using dual stable isotopic tracers | 2 months | |
Secondary | Change in bone turnover markers | Serum biochemical markers of bone turnover C-telopeptide (CTX) and procollagen type 1 N-terminal propeptide (P1NP) | 2 months | |
Secondary | Gastrointestinal tolerability | Self-reported flatulence, bloating, abdominal pain, stomach noises | 2 months | |
Secondary | Acceptability | Self-reported satisfaction, likelihood that one would be willing to consume the beverage for 12 months | 2 months | |
Secondary | Change in gut microbiome composition | Stool bacterial and fungal composition to be analyzed, including alpha diversity and beta diversity metrics as well as taxon relative abundance, with subsequent in silico metagenomic predictions of enrichment of bacterial functional gene pathways | 2 months |
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