Obesity Clinical Trial
Official title:
Cannabinoid CB1 Receptors in Human Brown Adipose Tissue
This study investigates cannabinoid CB1 receptors in human brown adipose tissue (BAT) and
other tissues using positron emission tomography (PET) imaging. Subjects will be scanned in
room temperature conditions and during controlled cold exposure, and the density of CB1
receptors in BAT and other tissues will be quantified. The investigators hypothesize, that
cannabinoid signaling is increased in cold conditions, when BAT is metabolically active.
Understanding the mechanisms of BAT activation and the role of endocannabinoids in humans is
important and beneficial in fighting against the epidemic of obesity and diabetes.
Endocannabinoids have an important role in regulating energy balance and metabolism.
Cannabinoid 1 receptors (CB1) are found in several tissues such as brown adipose tissue
(BAT). Endocannabinoids and CB1 receptors participate in the control of lipid and glucose
metabolism, and blockage of CB1 receptors has been found to improve metabolic factors linked
to obesity and cardiovascular disease, making CB1 antagonists potential drugs against obesity
and diabetes.
In this study the investigators use a PET radiotracer [18F]FMPEP-d2, which binds to CB1
receptors in vivo, to quantify the CB1 receptor density in BAT, white adipose tissue, muscle
and the brain. This study is done once in warm conditions and once during controlled cold
exposure. To verify whether the subject has metabolically active BAT, an additional PET scan
with the radiotracer [18F]FDG is performed.
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