Obesity Clinical Trial
— HYPOBESEOfficial title:
Changes in Body Composition, Metabolic and Mechanical Responses to Hypoxic Walking Training in Obese Patients
By analyzing energetic and biomechanical basis of walking, and the subsequent changes
induced by hypoxic vs normoxic training in obese individuals, it may optimize the use of
walking in hypoxia to gain perspective for exercise prescription to set up training programs
that aim to induce negative energy balance and to deal with weight management. However to
the investigators knowledge, the analysis of changes in mechanics, energetics and efficiency
of walking after continuous hypoxic training (CHT) has not been performed yet.
The aims of the present study were:
1. Comparing the changes in body composition between continuous hypoxic training (CHT) and
similar training in normoxia; e.g. continuous normoxic training (CNT) in obese
subjects.
2. Comparing the metabolic and energetics adaptations to CHT vs CNT.
3. Finally, comparing the associated body‐loss induced gait modification since walking
intensity at spontaneous walking speed (Ss) is lower in CHT than in CNT.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | July 2015 |
Est. primary completion date | July 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: - Healthy and free of clinically significant orthopaedic, neurological, cardiovascular or respiratory conditions. - BMI > 30 kg/m^2. - Age > 18 yr. Exclusion Criteria: - Age > 40 yr. - BMI < 35 kg/m^2. - Diabetes. - Neurological disorders, orthopaedic injury, history of falls and medications that provoke dizziness. |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Switzerland | Institute of Sport Sciences of the University of Lausanne | Lausanne | Vaud |
Lead Sponsor | Collaborator |
---|---|
University of Lausanne | Centre Hospitalier Universitaire Vaudois, CHUV - Centre des Maladies Osseuses - Département de l'Appareil Locomoteur (DAL) |
Switzerland,
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Faiss R, Léger B, Vesin JM, Fournier PE, Eggel Y, Dériaz O, Millet GP. Significant molecular and systemic adaptations after repeated sprint training in hypoxia. PLoS One. 2013;8(2):e56522. doi: 10.1371/journal.pone.0056522. Epub 2013 Feb 20. — View Citation
Haufe S, Wiesner S, Engeli S, Luft FC, Jordan J. Influences of normobaric hypoxia training on metabolic risk markers in human subjects. Med Sci Sports Exerc. 2008 Nov;40(11):1939-44. doi: 10.1249/MSS.0b013e31817f1988. — View Citation
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* Note: There are 16 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Body composition and mass | All subjects will undergo dual-energy X-ray absorptiometry (DEXA) and bio-impedance for measurements of body composition. | Change from baseline at 5 weeks (e.g., baseline and 5th week after inclusion) | No |
Primary | Net energy cost of walking | The subjects will be then asked to complete five 6 min level walking trials on the instrumented treadmill at five equally spaced speeds (0.55, 0.83, 1.11, 1.38 and 1.66 m/s), in randomized order. They will be allowed to establish their own preferred stride rate combination for each condition and will be given 5 min of rest between walking trials. During the walking trials, oxygen uptake (V?O 2), carbon dioxide (CO2) output (V?C O2) and ventilation (V? E) will be measured breath-by-breath (OxyconPro, Jaeger, Germany) and the volume and gases calibrations will be checked before each trial. Oxygen uptake values from the last 2 min will be averaged and normalized to body mass (V?O 2, mlO2·kg-1·min-1). This value minus resting V'O2 was then divided by walking speed to obtain the net energy cost of walking (mlO2·kg-1·m-1). | Change from baseline at 5 weeks (e.g., baseline and 5th week after inclusion) | No |
Primary | Mechanical external and internal work | During steady metabolic state (i.e., the last 2 min of walking for each speed), the mechanical external (Wext) and internal (Wint) work changes of 20 consecutive walking steps will be determined with an instrumented treadmill (H-P-COSMOS Treadmill MCU2 EPROM 2.31), consisting of a treadmill mounted on four 3-D force sensors, following the methods described in detail by Cavagna (Cavagna 1975) and Willems et al. (1995). | Change from baseline at 5 weeks (e.g., baseline and 5th week after inclusion) | No |
Primary | Efficiency | Total mechanical work and efficiency. The total mass-specific muscular work per distance travelled (Wtot) will be calculated as the sum of Wext and Wint. The mechanical efficiency will be computed as the ratio between Wtot and net energy cost of walking. | Change from baseline at 5 weeks (e.g., baseline and 5th week after inclusion) | No |
Secondary | Blood samples (this measure is a composite) | The blood samples were drawn at rest before (session 1) and after (session 12) the training program during fasting to determine total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides (TG), leptin, total adiponectin, resistin, retinol-binding protein 4 (RBP4), plasma glucose and insulin concentrations (this measure is a composite). | Change from baseline at 5 weeks (e.g., baseline and 5th week after inclusion) | No |
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