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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT01988441
Other study ID # 102066-F
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date September 2013
Est. completion date August 2025

Study information

Verified date September 2023
Source Far Eastern Memorial Hospital
Contact Yu-Cheng Lin, M.D., Ph.D.
Phone +886-89667000
Email q92421006@ntu.edu.tw
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. It is not known why only some obese subjects develop NAFLD. In recent years, a growing body of evidence showed a crucial role of autophagy in in the regulation of liver fat storage. The purpose of this study is to determine whether autophagy pathway-related genetic polymorphisms affect NAFLD.


Description:

The investigators will perform a prospective comparison of the genotype distribution of autophagy pathway-related genetic polymorphisms between those with and without NAFLD in a cohort of obese children and adolescents. [Subjects] Obesity is defined as the BMI value > 95 percentile by different age- and gender groups according to the standards of the Department of Health in Taiwan. [Data collection] The following data were obtained for each subject: age, gender, BMI, waist and hip circumference. The investigators will measure total serum bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase fasting glucose, triglyceride, total cholesterol, and high-density lipoprotein cholesterol, insulin, glucose, and adiponectin. [Liver ultrasonography] All participants will receive an ultrasonographic study of the liver. NAFLD is defined as the presence of an ultrasonographic pattern consistent with the following criteria: liver-kidney echo discrepancy, attenuated echo penetration and visibility of diaphragm, and obscure hepatic vessel structures. [Genotyping] Genomic DNA will be extracted from 3 cc venous blood from each participant. After extraction, the genomic DNA will be immediately stored at -80°C. The TaqMan genotyping assays will be performed for selected SNPs genotyping on ABI 7300 Real-Time PCR System (Applied Biosystems). [Sample size] Sample size was estimated by Epi InfoTM 7 (CDC, USA) program. Because there was no previous data regarding to the effect of autophagy related gene on NAFLD, the investigators estimate the odds ratio to vary between 60-80%. The investigators used a confidence level of 95%, power of 80%, the ratio of controls to NAFLD cases of 25%, percent of controls exposed of 25-35%, the samples size required would be a total of 291-872 subjects.


Recruitment information / eligibility

Status Recruiting
Enrollment 800
Est. completion date August 2025
Est. primary completion date August 2025
Accepts healthy volunteers No
Gender All
Age group 6 Years to 18 Years
Eligibility Inclusion criteria: - Age 6-18 years old - Obesity definition: BMI > 95% according to the age- and gender-specific standard by National Health Institute in Taiwan - Willing to give written informed consent Exclusion criteria: - Alcohol consumption - Chronic liver diseases, including hepatitis B, hepatitis C, Wilson disease and autoimmune hepatitis - Major systemic diseases, including cardiopulmonary disease, renal failure, cancer, and psychotic disorder

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
Taiwan Far Eastern Memorial Hospital New Taipei City

Sponsors (2)

Lead Sponsor Collaborator
Far Eastern Memorial Hospital Ministry of Science and Technology, Taiwan

Country where clinical trial is conducted

Taiwan, 

Outcome

Type Measure Description Time frame Safety issue
Primary The genotype distribution of autophagy pathway-related genetic polymorphisms between those with and without NAFLD The genotype distribution of autophagy pathway-related genetic polymorphisms between those with and without NAFLD One year
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