Longitudinal Follow-up of Brown Adipose Tissue Function and Structure

Obesity Clinical Trial

— BATFollowUp  

Official title:

Brown Adipose Tissue: Longitudinal Follow-up of Brown Adipose Tissue Structure and Associations With Obesity and Cardiovascular Risk Factors in Healthy Participants of Baseline PET Studies (BAT-Follow-Up)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01985503
• Other study ID #: BAT-Follow-Up
• Secondary ID: BATFOLLOWUP
• Status: Completed
• Start date: January 2015
• Est. completion date: December 31, 2017

Study information

• Verified date: May 2019
• Source: Turku University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

In Turku PET Centre, there have been 3 positron emission tomography studies on brown adipose tissue (BAT) activity in healthy adults. BATPET was performed between 2008 and 2009. FATBAT started in 2011 and Dixon-BAT in 2012 and they are both currently ongoing. In the current study, participants of BATPET, FATBAT and Dixon-BAT studies are recruited for a follow-up study to examine associations between obesity, cardiovascular risk factors, serum metabolic profile and BAT structure at baseline and during follow-up several years later. 43 BATPET participants will be called for follow-up in 2013 with a follow-up period of 5 years and 52 FATBAT and Dixon-BAT participants in years 2014 and 2015 with a follow-up period of 3 years. The aim of this study is to examine longitudinal associations between BAT function and structure, liver adiposity and cardiovascular risk factors at baseline and during follow-up.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 95
• Est. completion date: December 31, 2017
• Est. primary completion date: December 31, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 22 Years to 55 Years

Eligibility

Inclusion Criteria:

• All study subjects have been screened prior to acceptance in BATPET, FATBAT and Dixon-BAT studies and no screening for inclusion is required in the current study.

Exclusion Criteria:

• 1) Smoking 2) Blood pressure > 160/100 mmHg 3) Pregnancy or lactation 4) Medication (expected effect on study variables)

Related Conditions & MeSH terms

• Obesity

Locations

Country	Name	City	State
Finland	PET Centre, Turku University	Turku

Sponsors (1)

Lead Sponsor	Collaborator
Turku University Hospital

Country where clinical trial is conducted

Finland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Correlation between baseline brown adipose tissue activity according to PET imaging and serum lipoprotein concentrations at follow-up 5 years later	Brown adipose tissue activity is determined with FDG-PET imaging at baseline in 43 subjects and 5 years later the subjects participate a follow-up visit where lipoprotein levels are measured in mmol/l from serum samples. Correlation between brown adipose tissue activity and serum lipoproteins are examined with Pearson's correlation.	5 years
Secondary	Association between brown adipose tissue structure at baseline and at follow-up		5 years