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Effect of Caloric Restriction on Fat Oxidation in Obese Men and Women (Magellan II) — MagellanII  

Obesity Clinical Trial

Official title:
Effect of Caloric Restriction on Metabolic Biomarkers and Fat Oxidation in Obese Men and Women (Magellan II)

Clinical Trial Summary

The purpose of this study is to better understand the different ways our bodies burn fat which may be important for obesity, diabetes, and cardiovascular disease.

Clinical Trial Description

In this study the investigators will examine the hypothesis that overweight/obese individuals that are unable to meet target weight loss goals on a low calorie diet (LCD) are intrinsically less metabolically flexible than their weight-losing counterparts. The investigators expect that this 'inflexibility' will be characterized by impaired fat oxidation (as determined by indirect calorimetry) in response to caloric restriction. If this were the case, these subjects may represent a population of 'super-responders' likely to demonstrate a robust response to approaches to increase fat oxidation. The investigators will also measure lipid concentrations in skeletal muscle and liver by hydrogen 1 magnetic resonance (1H-MRS) to determine both the stability of these measurements as well as the magnitude of changes that can be seen during LCD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01616082
Study type Interventional
Source Translational Research Institute for Metabolism and Diabetes, Florida
Contact
Status Completed
Phase N/A
Start date September 2011
Completion date November 2012
View Details
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