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Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis

Obesity, Morbid Clinical Trial

Official title:
Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis

Clinical Trial Summary

It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss. Researchers will test the effects of inflammation and lipolysis regulation in people before and after bariatric surgery (sleeve gastrectomy) to answer these questions.

Clinical Trial Description

The purpose of this study is to determine whether the adipose inflammatory cell and cytokine content in Class III obesity is related to lipolysis insulin resistance and, if so, whether sustained, substantial weight loss one year following bariatric surgery reduces inflammation in parallel with improved insulin regulation of lipolysis ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03868592
Study type Interventional
Source Mayo Clinic
Contact
Status Recruiting
Phase N/A
Start date August 1, 2019
Completion date May 2025
View Details
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