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Nicotine Use Disorder clinical trials

View clinical trials related to Nicotine Use Disorder.

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NCT ID: NCT06259630 Withdrawn - Nicotine Addiction Clinical Trials

Nicotine Virtual Reality Conditioned Place Preference

NEVE
Start date: November 3, 2015
Phase: Phase 4
Study type: Interventional

In this between-subjects, placebo controlled, double-blind study, the investigators will examine the effects of low oral doses of nicotine on the learning and extinction of a conditioned place preference acquired in a virtual reality environment by healthy human subjects. Physiological and subjective responses to the drug will also be monitored.

NCT ID: NCT06170138 Recruiting - Clinical trials for Nicotine Use Disorder

Study to Assess PK, PD, Nicotine Extraction, Palatability, Subjective Effects of Nicotine Pouches - Daily Nicotine Users

Start date: November 24, 2023
Phase: N/A
Study type: Interventional

This is an explorative, open-label, randomised, 3-way cross-over study to assess pharmacokinetics (PK), pharmacodynamics (PD), safety and tolerability, nicotine extraction, palatability and subjective effects after single use of nicotine pouches in daily nicotine users.

NCT ID: NCT05994209 Not yet recruiting - Clinical trials for Nicotine Use Disorder

Testing the Feasibility and Acceptability of Social Media and Digital Therapeutics to Decrease Vaping Behaviors

Start date: January 2024
Phase: Phase 1
Study type: Interventional

Use of vaping products (e.g., electronic nicotine delivery systems, e-cigarettes) has been increasing rapidly, particularly among teens and young adults. With limited information on the long-term effects of vaping products, health information about vaping has been somewhat unclear in regards to associated health risks. Teens and young adults may be reluctant to disclose their use of vaping products to parents or health providers and instead turn to social media to share and seek out information regarding vaping risks and cessation supports. Thus, our current proposal outlines the use of social media to identify teens and young adults socially networking about vaping, the use of an online chatbot screen to evaluate individual cessation support needs, and the use of a digital intervention system to support vaping cessation. The mobile intervention used in this study is based on a widely-used evidence-based mobile intervention for combustible smoking (i.e., quitSTART) and has been adapted for vaping and young adults to include an in-app chatbot to guide users to tailored content and to motivate and encourage their cessation efforts. We aim to integrate our social media recruitment and online screening approach to connect individuals with this mobile app intervention, and will conduct a randomized controlled trial to evaluate user engagement with and preliminary efficacy of the digital intervention on reducing vaping behaviors among teens and young adults.

NCT ID: NCT05932745 Not yet recruiting - Clinical trials for Nicotine Use Disorder

Effects of Novel E-cigarette Constituents on Adults TCORS 3.0

Start date: November 2024
Phase: N/A
Study type: Interventional

This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.

NCT ID: NCT05897242 Completed - Nicotine Dependence Clinical Trials

A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults

Start date: January 4, 2024
Phase: N/A
Study type: Interventional

Almost one in ten young adults report current e-cigarette use, putting them at risk of developing nicotine addiction and long-term health effects of exposure to inhaled toxicants. Despite the need for effective treatments to help these young users quit, very few treatments targeting any type of tobacco use among young adults have been evaluated, particularly for young adults who vape and have unique treatment needs. To address these needs, this trial will evaluate a digital program for young adult e-cigarette users at all stages of readiness to quit called ACT on Vaping.

NCT ID: NCT05766254 Recruiting - Clinical trials for Nicotine Use Disorder

Identify the Optimal TMS Target to Modulate Reward Activity

Start date: March 24, 2023
Phase: N/A
Study type: Interventional

Our primary goal will be to identify the optimal prefrontal-cingulate target by systematically measuring the efficacy of various image-based targeting techniques to increase the reward positivity using the 10-Hz TMS protocol in dependent smokers. Our secondary objective will be to measure the targets' effectiveness to increase decision-making capacity using the probabilistic selection task (PST). Our third objective will be to specifically assess whether the TMS targets has a differential impact on state levels of craving relative to baseline (Tobacco Craving Questionnaire [TCQ]. We plan to accomplish these three objectives using a randomized, controlled experiment involving 3 sessions.

NCT ID: NCT05515354 Recruiting - Smoking Cessation Clinical Trials

Smoking Cessation and Menstrual Cycle Phase

MC-NRT
Start date: November 30, 2022
Phase: Phase 4
Study type: Interventional

Tobacco use is a risk factor for at least 20 types of cancer and remains the leading preventable cause of cancer in Canada. Smoking cessation is an important cancer prevention strategy for the close to 2 million Canadian women who currently smoke. However, findings from controlled trials and real-world clinical settings indicate that women have greater difficulty achieving abstinence following a quit attempt than men. There is some evidence that hormonal levels and fluctuations throughout the menstrual cycle (MC) may contribute to the greater difficulty women experience when trying to quit smoking. In this study, the start of a quit attempt using nicotine replacement therapy (NRT) will be targeted to specific phases of MC. It was hypothesized that starting a quit attempt during the first half of MC (follicular phase) will result in increased quit success compared to starting during the second half of MC (luteal phase) or the usual practice of not targeting quit start date to MC phase.

NCT ID: NCT05181891 Recruiting - Clinical trials for Alcohol Use Disorder (AUD)

Pharmaceutically-Enhanced Reinforcement for Reduced Alcohol and Smoking

PERRAS
Start date: July 11, 2022
Phase: Phase 2
Study type: Interventional

Using a randomized controlled trial (RCT), the goal of this study is to evaluate the ability of evidence based behavioral treatment (contingency management: CM) to significantly decrease alcohol use and cigarette smoking among treatment-seeking smokers with an alcohol use disorder (AUD) who have initiated pharmacotherapy (varenicline; VC) for smoking cessation.

NCT ID: NCT04772014 Completed - Clinical trials for Tobacco Use Disorder

Evaluation of the Addictive Potential of E-Cigarettes

EVAPE
Start date: December 1, 2020
Phase:
Study type: Observational

This study will examine the subject matter from a neurobiological and a neuropsychological vantage point to ascertain whether the e-cigarette is potentially as addictive as the traditional tobacco cigarette.

NCT ID: NCT04568395 Completed - Inflammation Clinical Trials

Acute Effects of TCIG vs ECIG in PLWH

Start date: October 1, 2020
Phase: N/A
Study type: Interventional

Randomized controlled trial of acute use of electronic cigarette or tobacco cigarette on parameters of ventricular repolarization and inflammation/oxidative stress.