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Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence — ChanBan  

Nicotine Dependence Clinical Trial

Official title:
Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence

Clinical Trial Summary

The objective of this proposal is to elucidate effects of bupropion SR + varenicline on smoking-cessation related processes in early abstinence using a human laboratory model. A within-subjects design will be used to assess the additive effects of bupropion and varenicline in 48 treatment seeking smokers [bupropion SR (300 mg/day)+placebo, varenicline (2 mg/day+placebo, and bupropion SR (300 mg/day)+varenicline (2 mg/day)]. Outcomes include withdrawal and craving, cognition, stress tolerance, anxiety, the reinforcing effects of smoking, and smoking topography. Hypotheses: We hypothesize that greatest treatment effects will be observed in the bupropion SR+varenicline group followed by varenicline+placebo and bupropion SR+placebo groups.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00749658
Study type Interventional
Source University of Minnesota
Contact
Status Completed
Phase Phase 2/Phase 3
Start date November 2008
Completion date September 2010
View Details
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