Neuropathic Pain Clinical Trial
— TRAP2-1Official title:
Screening for the Transthyretin-Related Familial Amyloidotic Polyneuropathy (TTR-FAP): An International, Multicenter, Epidemiological Protocol
NCT number | NCT01705626 |
Other study ID # | TRAP 08-2012 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | December 2016 |
Est. completion date | May 27, 2022 |
Verified date | May 2022 |
Source | CENTOGENE GmbH Rostock |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
An International, multicenter, epidemiological observational study investigating the prevalence of Transthyretin-Related Familial Amyloidotic Polyneuropathy (TTR-FAP) in participants with small fiber polyneuropathy of no obvious etiology.
Status | Completed |
Enrollment | 500 |
Est. completion date | May 27, 2022 |
Est. primary completion date | May 27, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 85 Years |
Eligibility | Inclusion Criteria: - Informed consent is obtained from the participant - The participant is aged between 18 and 85 years of age - The participant is diagnosed with small fiber polyneuropathy of no obvious etiology - The participant has no diagnosis of alcoholism, according to International Guidelines - The participant has not undergone chemotherapy for carcinoma Exclusion Criteria: - Inability to provide informed consent - The participant is younger than 18 years or older than 85 years of age - The etiology of the small fiber polyneuropathy is clearly determined - The participant has a diagnosis of alcoholism, according to International Guidelines - The participant has undergone chemotherapy for carcinoma |
Country | Name | City | State |
---|---|---|---|
Austria | Klinikum Wels-Grieskirchen GmbH, Abteilung für Neurologie | Wels | |
Hungary | University of Pécs, Department of Neurology | Pécs | |
Hungary | University of Szeged, Department of Neurology | Szeged | |
North Macedonia | University Hospital Skopje, Department of Neurology | Skopje | |
Poland | Jagiellonian University Medical College, Department of Neurology | Kraków | |
Serbia | Clinical Hospital Center Zvezdara, Department of Neurology | Belgrad | |
Serbia | University of Belgrade, Clinical Center of Serbia, Neurology Clinic, Neuropathy Center | Belgrade | |
Serbia | Clinical Center Niš, Department of Neurology | Niš | |
Serbia | General Hospital "Dr. Djordje Joanovic" | Zrenjanin | |
Spain | Hospital Infanta Leonor | Madrid | |
Spain | Hospital Universitario Donostia | San Sebastián |
Lead Sponsor | Collaborator |
---|---|
CENTOGENE GmbH Rostock |
Austria, Hungary, North Macedonia, Poland, Serbia, Spain,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Epidemiological analysis of prevalence of the TTR FAP in participants with small fiber polyneuropathy of no obvious etiology. | Dry Blood Spot (DBS) samples will be genetically validated via combination of Next-Generation Sequencing (the mutation will be confirmed by Sanger sequencing) and the Multiplex ligation-dependent probe amplification (MLPA) of TTR gene | 3 years | |
Secondary | Establishment of a biomarker in TTR-positive cohort | Samples carrying a mutation in the TTR gene will be biochemically analyzed via liquid chromatography multiple reaction monitoring MS and compared with a merged control cohort, in order to establish TTR mutation-specific biomarker/s. | 3 years |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04699734 -
Peripheral Nerve Block in Patients With Painful Diabetic Polyneuropathy
|
N/A | |
Recruiting |
NCT06019325 -
Rhomboid Intercostal Plane Block on Chronic Pain Incidence and Acute Pain Scores After Mastectomy
|
N/A | |
Completed |
NCT05235191 -
Effectiveness and Safety of Methadone Versus Placebo for the Control of Neuropathic Pain in Different Etiologies
|
Phase 3 | |
Completed |
NCT05845177 -
Persistent Pain After Hip Replacement
|
||
Completed |
NCT05496205 -
A SAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers
|
Phase 1 | |
Not yet recruiting |
NCT05949554 -
Electroencephalographic (EEG) Profils for Patients on Intravenous Ketamine.
|
||
Withdrawn |
NCT05052645 -
Ear Acupuncture for Neuropathic Pain
|
N/A | |
Completed |
NCT02866396 -
Impact of Pregabalin in Chronic Users vs. a Perioperative Limited Prescription on Oxycodone Requirement
|
||
Completed |
NCT02930551 -
Neuromas as the Cause of Pain
|
N/A | |
Completed |
NCT02824588 -
Working Memory Training for Chronic Neuropathic and Fibromyalgia Pain
|
N/A | |
Active, not recruiting |
NCT02560545 -
Cannabinoids Effects on the Pain Modulation System
|
N/A | |
Enrolling by invitation |
NCT02485795 -
Observational Study of the Impact of Genetic Testing on Healthcare Decisions and Care in Interventional Pain Management
|
N/A | |
Not yet recruiting |
NCT02246517 -
The Effect of N2O on Chronic Neuropathic Pain Patients
|
Phase 0 | |
Completed |
NCT02099890 -
The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury
|
Phase 3 | |
Completed |
NCT01946555 -
Prospective Longitudinal Observational Study to Evaluate the Clinical Characteristics and Opioids Treatments in Patients With Breakthrough Cancer Pain
|
N/A | |
Completed |
NCT01884662 -
Virtual Walking for Neuropathic Pain in Spinal Cord Injury
|
N/A | |
Completed |
NCT01718821 -
Assessments on Current Pain Managements in Upper Gastrointestinal Cancer Patients
|
N/A | |
Completed |
NCT01669967 -
The Role of Intravenous (IV) Lidocaine in the Management of Chronic Neuropathic Pain of Peripheral Nerve Origin
|
N/A | |
Completed |
NCT01207596 -
Evaluating the Efficacy and Safety of Extended Release Hydromorphone (Exalgo) in Patients With Neuropathic Pain
|
Phase 4 | |
Completed |
NCT01201317 -
A Study to Investigate the Analgesic Efficacy of AZD2423 Compared With Placebo After 28 Days Treatment in Patients With Painful Diabetic Polyneuropathy
|
Phase 2 |