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Clinical Trial Summary

This is a phase I study of 177Lu-DOTA-TATE in combination with the PARP-inhibitor olaparib for treatment of patients with somatostatin receptor positive tumours detected by 68Ga-DOTA-TATE/TOC PET. The combination of a PARP inhibitor that will specifically target the repair mechanism, with ionising radiation causing SSB's might overcome the repair dependent survival of the tumour cells, making them more sensitive to β-emission and increase the probability of tumour cell death.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04375267
Study type Interventional
Source Vastra Gotaland Region
Contact
Status Active, not recruiting
Phase Phase 1
Start date April 23, 2020
Completion date June 30, 2024

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