CYP2D6 Pharmacogenetics in Risperidone-Treated Children

Status Completed

Clinical Trial Summary

Risperidone is an important medication used to treat children with psychiatric illnesses or neurodevelopmental disorders, such as autism. Despite excellent symptom control, the potential for side effects is worrisome. Treating these disorders is difficult because not everyone responds the same way to the same risperidone dose. One reason for this is genetic differences in how people break down the drug. Understanding these differences will help clinicians choose a dose and better predict the response so patients will be treated successfully with a lower risk for side effects. This study will research these genetic differences in children with psychiatric or neurodevelopmental disorders. Hypothesis: The inter-patient variability in risperidone pharmacokinetics and exposure, adverse events, and clinical response in patients with psychiatric or neurodevelopmental disorders is associated with identifiable pharmacogenetic factors, such as CYP2D6 single nucleotide polymorphisms (SNPs).

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00783783
Study type	Observational
Source	Children's Hospital Medical Center, Cincinnati
Contact
Status	Completed
Phase	N/A
Start date	November 2008
Completion date	June 2011

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03148782` - Brain Plasticity Underlying Acquisition of New Organizational Skills in Children-R61 Phase	N/A
Active, not recruiting	`NCT04935593` - Strengthening Social, Emotional and Behavioral Resilience	N/A
Recruiting	`NCT03222375` - SQUED™ Series 28.1 Home-use and Treatment of Autowave Reverberator of Autism	N/A
Completed	`NCT04313283` - Translating Peer-to-Peer Support Into a Clinical Setting	N/A
Completed	`NCT04562935` - Long-term Consequences of Admission for Pediatric Intensive Care Before One Year of Age
Not yet recruiting	`NCT05815095` - Early Detection and Referral for Autism and Neurodevelopmental Disorders at the Maternal and Child Protection Services
Recruiting	`NCT05017363` - Evaluation of the Effectiveness of Child-oriented Goal-setting in Paediatric Rehabilitation (the ENGAGE Approach)	N/A
Completed	`NCT06251830` - Increasing Diagnosis Rates While Reducing Examination Time: Can MR Fingerprinting Deliver on Its Promise?
Completed	`NCT06052878` - Neurodevelopmental Outcome After Prenatal Anesthesia
Recruiting	`NCT06012903` - Lower Urinary Tract Symptoms and School Functioning in Children
Not yet recruiting	`NCT05490173` - The Pilot Experimental Study of the Neuroprotective Effects of Exosomes in Extremely Low Birth Weight Infants	N/A
Not yet recruiting	`NCT06081348` - Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders	Phase 2
Not yet recruiting	`NCT05564871` - Effectiveness of Occupational Therapy Teleintervention in Pediatric	N/A
Enrolling by invitation	`NCT02871674` - Good Night Project: Behavioural Sleep Interventions for Children With ADHD: A Randomised Controlled Trial	N/A
Completed	`NCT01922791` - Nutrition and Pregnancy Intervention Study	N/A
Active, not recruiting	`NCT05428657` - EC Brain Program for Children With Special Education Needs	N/A
Recruiting	`NCT06111898` - Neuro-biomechanical Determinants for Motor Behavior in High-risk Infants
Recruiting	`NCT05658965` - KIDSHEART AND BRAIN : Early EEG Surgery Congenital Heart Disease Predict Onset of Neurodevelopmental Disorders
Recruiting	`NCT06086951` - Pai.ACT - An Artificial Intelligence Driven Chatbot Assisted ACT	N/A
Recruiting	`NCT05997680` - A Parent-child Yoga Intervention for Reducing Attention Deficits in Children With Congenital Heart Disease: A Feasibility Study	N/A