Nephrotic Syndrome in Children Clinical Trial
Official title:
The Canadian Childhood Nephrotic Syndrome (CHILDNEPH) Project
CHILDNEPH is a pan-Canadian project to observe clinical care for children with nephrotic syndrome. Previous studies have indicated that there is wide practice variation in how health care providers treat this remitting and relapsing disease of childhood. The disease mechanism is not yet understood, and long-term use of steroids can affect children's health. This study involves assessment of routine clinical care and establishing a long-term patient registry for children with nephrotic syndrome.
CHILDNEPH is an ongoing prospective longitudinal study of children with incident and
prevalent nephrotic syndrome. Children are recruited from 12 centres across Canada and
followed for at least 30 months. The project starting in August of 2013 with the goal of
following 400 patients. Data is collected at enrollment, beginning and end of each relapse,
semi-annual visits and end of study. Detailed prescription data is collected regarding
glucocorticoids and all second line agents. All relapses are recorded with time to urinary
remission of proteinuria.
The investigators are moving towards registry based trials to determine optimal treatment
protocols for nephrotic syndrome with an overall goal to minimize glucocorticoid exposure, a
patient priority.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
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|
Phase 2 | |
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Phase 3 | |
| Not yet recruiting |
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|
||
| Terminated |
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Phase 4 | |
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