Nephrotic Syndrome in Children Clinical Trial
Official title:
The Canadian Childhood Nephrotic Syndrome (CHILDNEPH) Project
CHILDNEPH is a pan-Canadian project to observe clinical care for children with nephrotic syndrome. Previous studies have indicated that there is wide practice variation in how health care providers treat this remitting and relapsing disease of childhood. The disease mechanism is not yet understood, and long-term use of steroids can affect children's health. This study involves assessment of routine clinical care and establishing a long-term patient registry for children with nephrotic syndrome.
CHILDNEPH is an ongoing prospective longitudinal study of children with incident and
prevalent nephrotic syndrome. Children are recruited from 12 centres across Canada and
followed for at least 30 months. The project starting in August of 2013 with the goal of
following 400 patients. Data is collected at enrollment, beginning and end of each relapse,
semi-annual visits and end of study. Detailed prescription data is collected regarding
glucocorticoids and all second line agents. All relapses are recorded with time to urinary
remission of proteinuria.
The investigators are moving towards registry based trials to determine optimal treatment
protocols for nephrotic syndrome with an overall goal to minimize glucocorticoid exposure, a
patient priority.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05044169 -
Efficacy and Safety of Broncho-Vaxom in the First Episode of Pediatric Idiopathic Nephrotic Syndrome
|
N/A | |
| Recruiting |
NCT05583942 -
A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS)
|
N/A | |
| Recruiting |
NCT05588063 -
taVNS for FRNS in Children
|
N/A | |
| Recruiting |
NCT06125405 -
Study of the Telitacicept in Pediatric Patients With Frequently Relapsing or Steroid Dependent Nephrotic Syndrome
|
Phase 3 | |
| Completed |
NCT04034316 -
Reduce Immunosuppression With Atmp in NS ChildrEn
|
Phase 2 | |
| Completed |
NCT04048161 -
Study of Tacrolimus vs Mycophenolate Mofetil in Pediatric Patients With Nephrotic Syndrome
|
Phase 4 | |
| Recruiting |
NCT06079788 -
Study of Adrenocorticotropic Hormone on Children With Frequent Relapse or Steroid-dependent Nephrotic Syndrome: a Prospective, Multicenter, Randomized，Open-label Clinical Trial.
|
Phase 3 | |
| Enrolling by invitation |
NCT04571658 -
NEPTUNE Match Study
|
||
| Recruiting |
NCT05843968 -
Efficacy and Safety of Rituximab Versus Mycophenolate Mofetil in Children With Steroid-dependent Nephrotic Syndrome
|
Phase 2 | |
| Recruiting |
NCT05734794 -
Study of Rituximab Monotherapy on Children With New-onset Nephrotic Syndrome: A Randomized Controlled Trial
|
Phase 3 | |
| Not yet recruiting |
NCT06130631 -
Predictors of Steroid Response in Childhood Nephrotic Syndrome
|
||
| Terminated |
NCT03878914 -
Steroid Sensitive Nephrotic Syndrome in Children
|
Phase 4 | |
| Recruiting |
NCT05772871 -
The Efficacy and Safety of Prednisone Combined With Huaiqihuang Granule for Primary Nephrotic Syndrome in Children
|
Phase 4 | |
| Recruiting |
NCT05505500 -
Interview Study of Adult and Child Patients and Parents of Children With Swelling Due to Nephrotic Syndrome.
|