Clinical Trials Logo
  1. Home
  2. Necrotic Pulp
  3. NCT04983524
  4. Details
NCT04983524 Clinical Trial

Propolis Versus Calcium Hydroxide on Post-Operative Pain in Patients With Necrotic Pulp

Necrotic Pulp Clinical Trial

Official title:
Evaluation of the Effect of Propolis Versus Calcium Hydroxide, Intracanal Medicaments on Post-Operative Pain in Patients With Necrotic Pulp (A Randomized Clinical Trial)

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04983524
Other study ID # SSirry
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date October 2015
Est. completion date May 2018

Study information
Verified date July 2021
Source Cairo University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Propolis is a resinous product of honeybees. Propolis is said to be effective against resistant microorganisms inside the root canal compared to the gold standard medication known as calcium hydroxide. The clinical trial tests the effect of propolis versus calcium hydroxide on pain in patients with necrotic teeth.

Description:

Propolis is an immunomodulatory, antioxidant, flavonoid-rich resinous product of honeybees. Propolis was reported as less cytotoxic and more effective against resistant microorganisms than calcium hydroxide as well as biocompatible to the periradicular tissues than existing intracanal medicaments. The aim of this single-blinded randomized clinical trial was to evaluate the effect of propolis versus calcium hydroxide, intracanal medicaments, on post-operative pain in patients with necrotic single canal teeth. Methods: Forty-six participants with an age range of 20-40 years old, diagnosed as having necrotic pulp in their single-rooted, single canal teeth were included in this study, with 23 participants in each group. Treatment was done in two visits and intracanal medicament was applied for one week in between. Participants were instructed to rate their pain score by a numerical rating scale after 24, 48, 72 hours and at 7 days.

Recruitment information / eligibility
Status Completed
Enrollment 46
Est. completion date May 2018
Est. primary completion date May 2018
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 20 Years to 40 Years
Eligibility Inclusion Criteria: - • Asymptomatic patients with age range 20 - 40 years - Necrotic, single canal maxillary and mandibular teeth with periapical infection presented as radiolucency or widening in the periodontal membrane space. - Medically - free of any systemic disease - Teeth with complete root formation Exclusion Criteria: - • Pregnant or lactating females - Teeth with vital pulps, internal or external resorption or anatomic abnormalities - Teeth with cracks, curvatures, root caries and calcified canals - Double or triple-rooted teeth - Patients with facial swelling, acute pulpal or periapical lesion - Teeth that are not indicated for endodontic treatment: Bad oral hygiene, mobile or recessed - Previously endodontically-treated teeth

Study Design

Related Conditions & MeSH terms

Intervention

Dietary Supplement:
• propolis
resinous product of honeybees
Drug:
• Calcium Hydroxide
Gold standard control intracanal medicament

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Cairo University

Outcome
Type Measure Description Time frame Safety issue
Primary post-operative pain Categorical data on numerical rating scale one week. line of 10 points
See also
  Status Clinical Trial Phase
Not yet recruiting NCT04035330 - Effect of Etidronate in Sodium Hypochlorite Versus Sodium Hypochlorite on the Intensity of Postoperative Pain N/A
Completed NCT06418386 - Bacterial Reduction of Rotary Versus Manual Filing System Using Different Irrigants in Primary Molars N/A
Not yet recruiting NCT05522270 - Concentrated Growth Factor Versus Platelet Rich Fibrin in Revitalization of Necrotic Young Permanent Incisors N/A
Completed NCT04606719 - Healing Potentiality Of Blood Clot S-PRF and A-PRF in the Treatment Of Necrotic Mature Single-Rooted Teeth With Chronic Peri-Apical Periodontitis N/A
Not yet recruiting NCT05988788 - Effect of Epigallocatechin-3-Gallate Solution as a Root Canal Irrigant on Post-Operative Pain Intensity and Bacterial Load Reduction in Necrotic Tooth N/A
Not yet recruiting NCT06116214 - Effect of Vachellia Nilotica Versus Sodium Hypochlorite as Root Canal Irrigant on Postoperative Pain and Bacterial Load Reduction in Mandibular Premolar Teeth With Necrotic Pulp Phase 4
Not yet recruiting NCT03698188 - Comparative Evaluation of the Regenerative Capacity of Two Platelet Concentrates N/A
Not yet recruiting NCT05289843 - Rosmarinus Officinalis Versus 2.5%Sodium Hypochlorite as Root Canal Irrigants N/A
Not yet recruiting NCT06310044 - Effect of Commiphora Myrrh Solution as a Root Canal Irrigant on Post Operative Pain and Bacterial Load Reduction in Necrotic Tooth N/A
Completed NCT03084601 - Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy Phase 4
Not yet recruiting NCT03059290 - Incidence of Post-Operative Pain After Single Visit Root Canal Treatment in Necrotic Teeth Using Two Different Rotary Systems (Protaper Nex t& Neolix File) N/A
Completed NCT04646538 - Volume Assessment of the Periapical Healing Following Regenerative Endodontic Procedures Using Cone- Bean Computed Tomography Early Phase 1
Completed NCT03708081 - Comparative Evaluation of Different File Systems in Postoperative Pain
Not yet recruiting NCT05419752 - Clinical Assessment of 3 Differant Obturation Sealers on Postoprative Pain and Swelling Phase 2/Phase 3
Completed NCT05775081 - Treated Dentine Matrix and Platelet Rich Fibrin in Induction of Root Formation of Non-Vital Immature Permanent Teeth N/A
Not yet recruiting NCT03009006 - Post Operative Pain and Level of Endotoxins With Calcium Hydroxide and Calcium Hydroxide Mixed With Chlorhexidine in Treating Necrotic Teeth N/A
Not yet recruiting NCT05620147 - Effect of Apical Enlargement to Different Preparation Sizes and Tapers on Pain and Bacterial Reduction in Necrotic Pulp N/A
Not yet recruiting NCT05146713 - Effect of Propolis Nanoparticles on Postoperative Pain and Bacterial Reduction in Mandibular Premolars Phase 2/Phase 3
Not yet recruiting NCT04035070 - Effect of Irrigation With Antibiotic-containing Solutions on Postoperative Pain and Intra-canal Bacteria Phase 4
Not yet recruiting NCT04728386 - Postoperative Pain and Antibacterial Efficacy After Root Canal Irrigation With Curcumin or Sodium Hypochlorite N/A