Myocardial Ischemia Clinical Trial
Official title:
Peripheral Endothelial Function and Coronary Status in Asymptomatic Type 2 Diabetic Patients: Relations With Coronary Microcirculation Assessed With Trans-thoracic Echo-doppler
Silent myocardial ischemia is usual in type 2 diabetic patients and associated with coronary stenoses and endothelial dysfunction or both. We therefore hypothesized that peripheral endothelial dysfunction is a marker of silent myocardial ischemia. The aim of the study is, in 120 asymptomatic type 2 diabetic patients, to evaluate the relations between coronary status, assessed with myocardial scintigraphy and subsequent coronary angiography in case of abnormality, and peripheral endothelial function, according to post-occlusive hyperaemia endothelium-dependent brachial artery dilation.
Coronary microcirculation, non invasively assessed with trans-thoracic echo-doppler
(coronary blood flow before and after cold pressure testing), and biochemical markers of
endothelial dysfunction will also be measured. Correlations between peripheral and coronary
endothelial functions will be checked. The measurements will be performed and validated in
two other groups
- 30 patients with overweight but free of diabetes, matched with the patients with
diabetes for age, gender and body mass index
- 30 control subjects.Reproducibility of the methods will be assessed in 10 patients of
the three groups of subjects.
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Observational Model: Case Control, Time Perspective: Prospective
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