Acute Effects of HIIT vs. MICT on HRV

Myocardial Infarction Clinical Trial

— MW2acute  

Official title:

Acute Effects of High Intensity Interval Training (HIIT) vs. Moderate Intensity Continuous Training (MICT) on Heart Rate Variability Parameters in Patients After Myocardial Infarction

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06437145
• Other study ID #: UKCLRehab2024/1
• Status: Recruiting
• Phase: N/A
• Start date: February 15, 2024
• Est. completion date: June 15, 2024

Study information

• Verified date: May 2024
• Source: University Medical Centre Ljubljana
• Contact: Marko Novakovic, MD, PhD
• Phone: 0038615228032
• Email: marko.novakovic[@]kclj.si
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Heart rate variability (HRV) is impaired in patients after myocardial infarction. Most studies so far have proved chronic beneficial effects of different types of exercise on HRV parameters. Data on acute effects of different types of exercise training (e.g. high intensity interval training [HIIT] and moderate intensity continuous training [MICT]) is scarce.

Patients in the study will perform both HIIT and MICT in a random order and in-between break of at least 48 hours. A 5-minute high resolution ECG recording will be performed before and immediately after both HIIT and MICT.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: June 15, 2024
• Est. primary completion date: June 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• myocardial infarction in last 120 days

• sinus rhythm

Exclusion Criteria:

• contraindications for exercise training

• uncontrolled dysrhythmias

• Heart Failure NYHA IV stage

• cognitive impairment

• pregnancy

Related Conditions & MeSH terms

• Infarction
• Myocardial Infarction

Intervention

Other:
• Type of Exercise
The high-intensity interval training session consists of 5-min warm-up and 5-min cool-down periods. The main part has 7 cycles. Each cycle consists of 1.5 min of 80-90% of HRpeak and 3 min of 65-70% of HRpeak. The moderate-intensity continuous training session consists of 5 min warm-up and 3-min cool down period. The main part consists of 32 min of 75% of HRpeak.

Locations

Country	Name	City	State
Slovenia	University Medical Centre Ljubljana	Ljubljana

Sponsors (1)

Lead Sponsor	Collaborator
University Medical Centre Ljubljana

Country where clinical trial is conducted

Slovenia, 

References & Publications (3)

El-Malahi O, Mohajeri D, Mincu R, Bauerle A, Rothenaicher K, Knuschke R, Rammos C, Rassaf T, Lortz J. Beneficial impacts of physical activity on heart rate variability: A systematic review and meta-analysis. PLoS One. 2024 Apr 5;19(4):e0299793. doi: 10.1371/journal.pone.0299793. eCollection 2024. — View Citation

Grassler B, Thielmann B, Bockelmann I, Hokelmann A. Effects of different exercise interventions on heart rate variability and cardiovascular health factors in older adults: a systematic review. Eur Rev Aging Phys Act. 2021 Nov 17;18(1):24. doi: 10.1186/s11556-021-00278-6. — View Citation

Routledge FS, Campbell TS, McFetridge-Durdle JA, Bacon SL. Improvements in heart rate variability with exercise therapy. Can J Cardiol. 2010 Jun-Jul;26(6):303-12. doi: 10.1016/s0828-282x(10)70395-0. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Non-linear methods	SD1, SD2	5-minutes high resolution ECG recording before and after an exercise session
Primary	HF parameter	High frequency domain of the HRV	5-minutes high resolution ECG recording before and after an exercise session
Secondary	LF parameter	Low frequency domain of the HRV	5-minutes high resolution ECG recording before and after an exercise session
Secondary	SDNN	Standard deviation of NN intervals	5-minutes high resolution ECG recording before and after an exercise session
Secondary	RMSSD	Root mean square of successive RR interval differences	5-minutes high resolution ECG recording before and after an exercise session
Secondary	pNN50	Percentage of successive RR intervals that differ by more than 50 ms	5-minutes high resolution ECG recording before and after an exercise session