Two- Dimensional Speckle Tracking Echocardiography After Primary Percutaneous Coronary Intervention

Myocardial Infarction Clinical Trial

Official title:

The Role of Two- Dimensional Speckle Tracking Echocardiography in Prediction of Remodeling and Major Adverse Cardiovascular Events in ST Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04228510
• Other study ID #: 2DSE
• Status: Not yet recruiting
• Start date: March 2020
• Est. completion date: December 2021

Study information

• Verified date: January 2020
• Source: Assiut University
• Contact: Aly Tohamy, MD
• Phone: 01006258877
• Email: Ali.tohamy[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

ST-segment elevation myocardial infarction (STEMI) is a major cause of morbidity and mortality worldwide. In spite of decrease in acute and long-term mortality following STEMI in parallel with more use of reperfusion therapy, such as primary percutaneous coronary intervention (PPCI), modern antithrombotic therapy, and secondary prevention, mortality remains considerable. Reduced EF is a well-known predictor of increased short and long term major adverse cardiovascular events MACE :( heart failure, stroke and death)

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 204
• Est. completion date: December 2021
• Est. primary completion date: September 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• ST elevation myocardial infarction patients after primary percutaneous coronary intervention

Exclusion Criteria:

• Previous myocardial infarction.

• Sever or haemodynamically significant (associated with chamber dilation) valvular heart diseases.

• Previous heart failure.

• Previous cerebrovascular strokes.

• Atrial fibrillation.

• Severe comorbidities as severe renal impairment, hepatic or respiratory failure.

• Bad equality views which affects accurate speckle tracking imaging.

Related Conditions & MeSH terms

• Infarction
• Myocardial Infarction

Intervention

Procedure:
• 2D speckle tracking echocardiography
Global and segmental strain and strain rate in longitudinal and circumferential directions will be detected after PPCI; before discharge. The LV circumferential strains and strain rates will be determined from the short-axis views at the basal, middle, and apical levels, and longitudinal strains and strain rates will be determined from the apical 2-, 3-, and 4-chamber views of the LV. Segmental longitudinal strains equal to -15% or closer to 0 will be considered abnormal (injured segments). The average segmental longitudinal strain and strain rate of the abnormal segments is defined as the injury longitudinal strain (InjLS) and injury longitudinal systolic strain rate (InjLSRs).

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The Incidence of major adverse cardiovascular events	the rate of Acute coronary syndrome, Heart failure, Stroke and all-cause mortality	1 year