Left Ventricular Function After Primary Percutaneous Coronary Intervention: Role of Speckle Echocardiography

Myocardial Infarction Clinical Trial

Official title:

Effect of Residual Myocardial Ischemia on Recovery of Left Ventricular Function After Primary Percutaneous Coronary Intervention

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04103008
• Other study ID #: AssiutU2019
• Status: Not yet recruiting
• Start date: November 1, 2019
• Est. completion date: December 1, 2020

Study information

• Verified date: September 2019
• Source: Assiut University
• Contact: Karim ME Aly
• Phone: 01068545195
• Email: karimeltaher294[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Recovery of the left ventricular function is variable from one patient to another, thus assessment of cardiac function by measuring left ventricular ejection fraction using echocardiography is the most common in the daily clinical practice. However, this technique has limitation related with its intra- and interobserver variability. A recent technique, 2D speckle tracking for assessing global longitudinal strain, has been introduced to reduce the variability and potentially has a higher accuracy. Speckle tracking is a method which uses two dimensions recording for measuring quantity of movement of myocardium in several segments.

Speckle-tracking echocardiography is a current noninvasive ultrasound imaging technique that allows for an objective and quantitative evaluation of global and regional myocardial function independently from the angle of insonation and from cardiac translational movements,

Description:

Authors using 2D speckle tracking found that subclinical LV systolic dysfunction is common in patients with isolated severe mitral stenosis (MS) and is determined primarily by the hemodynamic variables of MS severity and reduced LV filling. BMV results in rapid recovery of LV systolic function in these patients through improvement in LV diastolic loading. These findings suggest that LV contractile properties in MS are modulated predominantly by LV diastolic filling rather than myocardial structural abnormality.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 100
• Est. completion date: December 1, 2020
• Est. primary completion date: September 1, 2020
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Patients with acute myocardial infarction eligible for PCI seen on admission and after 40 days

Exclusion Criteria:

• cardiomyopathy

• cancer

• on cytostatic treatment.

Related Conditions & MeSH terms

• Echocardiography 2D
• Infarction
• Left Ventricular Dysfunction
• Myocardial Infarction
• Ventricular Dysfunction
• Ventricular Dysfunction, Left

Intervention

Diagnostic Test:
• Speckle tracking echocardiography
assess left ventricular function on admission and after 40 days

Locations

Country	Name	City	State
Egypt	Assiut University Hospitals	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Assessing change of left ventricular function	measure ejection fraction	baseline and after 40 days of PCI
Secondary	Major adverse cardiovascular events	non fatal myocardial infarction, non fatal stroke, CV death	40 days